Insight on Genotoxicity

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Genetic toxicology is essential for assessing the genetic impact of artificial chemicals. Insight on Genotoxicity provides an overview of testing, mechanisms, prediction, and bioin dicators of genotoxicity, including advances in nano-engineered particles and the corollary of DNA damage. It also discusses a perspective review of genotoxicity evaluation in phytopharmaceuticals and the prevention of genotoxicity. The book offers methods, standard protocols, and guidelines for genotoxicity testing, examines the impact of ICH Guidelines, and highlights advances in in vivo genotoxicity testing, computational prediction, and drug development. Format: Hardback Length: 152 pages Publication date: 15 October 2020 Publisher: Taylor & Francis Ltd Genetic toxicology is a crucial assessment tool due to the genetic impact of artificial chemicals. In-depth exploration into genotoxicity is provided in Insight on Genotoxicity, which covers testing, mechanisms, prediction, and bioindicators, considering recent advancements in nano-engineered particles. The corollary of DNA damage is explored, emphasizing the influence of ICH guidelines on genotoxicity testing, which is vital for drug discovery innovation and development. A comprehensive perspective review of genotoxicity evaluation in phytopharmaceuticals is also discussed, along with a brief viewpoint on preventing genotoxicity.Salient Features:The book offers comprehensive methods, standard protocols, and guidelines for conducting genotoxicity testing.It examines the impact of ICH Guidelines on genetic toxicity testing, a regulatory requirement in drug discovery and development.Appropriate strategies for advancing in vivo genotoxicity testing, including in silico and in vitro methods, are discussed.Progress and prospects in high-throughput approaches for genotoxicity testing are highlighted.Computational prediction of genotoxicity is explored, considering mutagenicity, chromosomal damage, and strategies for computational prediction in drug development.Overall, this book serves as a valuable resource for researchers, scientists, and regulatory professionals involved in genotoxicity testing and drug development. Weight: 364g Dimension: 162 x 242 x 10 (mm) ISBN-13: 9780367473372 Show more