SUPPORTS THE HEALTHY BALANCE OF BACTERIA* BERBERINE COMPLEX OFFERS TRADITIONAL GASTROINTESTINAL SUPPORT* Berberine Complex is formulated to support the healthy balance of bacteria.*1 HOW IT WORKS Berberine is a constituent of some plants including Barberry (Berberis vulgaris), Oregon Grape (Berberis aquifolium), and Goldenseal (Hydrastis canadensis). Berberine Complex contains extracts of berberine-containing plants: barberry, Oregon grape, and goldenseal. In addition to berberine, Goldenseal extract also contains other alkaloids such as hydrastine. Traditional use of herbs and extracts often rely on the complex nature of plants rather than isolated bioactive compounds. Berberine Complex is intended for traditional gastrointestinal support.* BERBERINE SUPPORTS HEALTHY BALANCE OF BACTERIA* Goldenseal, which contains alkaloids including berberine, has been traditionally used in North American for gastrointestinal support.* Mechanistic studies in animals and cell culture models suggest berberine may modulate gut microbiota by binding to DNA of bacteria.1-3 In animal and cell culture studies, berberine has demonstrated an ability to support the intestinal microenvironment.1 In a human Caco-2 cell model, berberine exhibited an ability to maintain tight junctions and support epithelial barrier function.4 REFERENCES Imenshahidi M et al. Phytother Res. 2016;30:1745-64. Habtemariam S. Pharmacol Res. 2020;155:104722. Tian Y et al. Drug Metab Dispos. 2019;47:86-93. Cao M et al. PLoS ONE. 2013;8(5):e61944.
