Ipamorelin

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Ipamorelin Description Ipamorelin is a synthetic peptide studied extensively as a growth hormone secretagogue in laboratory research. This compound belongs to the growth hormone-re leasing peptide (GHRP) class and serves as a research tool for examining pituitary receptor interactions and growth hormone release mechanisms. Ipamorelin is a pentapeptide (composed of 5 amino acids) that functions as a ghrelin mimetic in experimental models. Developed in the 1990s for research applications, this compound demonstrates selective growth hormone release properties without affecting other pituitary hormones, distinguishing it from earlier-generation peptides in laboratory studies. The compound shows high specificity for the GHS-R1a receptor, enabling targeted investigation of physiological responses in vitro. Its selective mechanism has established it as a valuable research tool for investigating growth hormone signaling pathways, metabolic regulation, and receptor-ligand interactions in scientific studies. Peptide Information Property Value Peptide Sequence Aib-His-D-2Nal-D-Phe-Lys Molecular Formula C38H49N9O5 Molecular Weight 711.9 g/mol CAS Number 170851-70-4 PubChem CID 9831659 Synonyms 170851-70-4, Ipamorelin [INN], NNC-26-0161, UNII-Y9M3S784Z6 Ipamorelin Research What is the research background of Ipamorelin? Delayed gastric emptying is a common condition, and currently, there are few effective treatment options. Research has found that Ipamorelin, as a synthetic peptidomimetic, acts on the ghrelin receptor and may have a therapeutic effect on delayed gastric emptying. In a study on a rodent model of gastroparesis, gastroparesis was induced by abdominal surgery and intestinal manipulation, and it was found that Ipamorelin could accelerate gastric emptying[1]. Postoperative ileus is a significant challenge in clinical practice, lacking effective management strategies. Ghrelin receptor stimulation has a motility-promoting effect on both the upper and lower parts of the gastrointestinal tract. As a ghrelin receptor agonist, Ipamorelin has potential application value in the treatment of postoperative ileus. For example, in a study, a prospective, randomized, controlled proof-of-concept study was conducted on patients undergoing intestinal resection after abdominal surgery to evaluate the safety and effectiveness of Ipamorelin[2]. Ipamorelin belongs to the growth hormone releasing peptides (GHRPs), which is a synthetic pentapeptide capable of stimulating the release of growth hormone from the hypothalamus and pituitary gland. Growth hormone plays an important role in the body's growth, repair, and metabolism, so the role of Ipamorelin in regulating growth hormone has also attracted widespread attention[3]. Due to its potential value in treating delayed gastric emptying, postoperative ileus, and its role as a growth hormone releasing peptide, Ipamorelin has attracted extensive research attention. What is the mechanism of action of Ipamorelin? 1. Stimulating the release of growth hormone: Ipamorelin belongs to the growth hormone releasing peptides (GHRPs), which can stimulate the release of growth hormone from the hypothalamus and pituitary gland. In vitro and in vivo experiments, Ipamorelin has shown high potency and efficacy in releasing growth hormone. For example, in a study, the potency and efficacy of Ipamorelin in releasing growth hormone from primary rat pituitary cells were similar to those of GHRP-6[3]. Its mechanism of action is to stimulate the release of growth hormone by activating GHRP-like receptors. Through pharmacological analysis, it has been confirmed that like GHRP-6, Ipamorelin stimulates the release of growth hormone through GHRP-like receptors. 2. Effects on the gastrointestinal tract Accelerating gastric emptying: In rodent models, Ipamorelin can accelerate gastric emptying. Abdominal surgery leads to delayed gastric emptying, but after administration of Ipamorelin (0.014 µmol/kg intravenously), gastric emptying is significantly accelerated. Ipamorelin stimulates gastric contractility and accelerates gastric emptying through a mechanism mediated by the activation of the ghrelin receptor, involving cholinergic excitatory neurons (Greenwood-Van Meerveld B, 2012). Improving symptoms of postoperative ileus: In rodent models of postoperative ileus, Ipamorelin may improve the symptoms. After postoperative administration of Ipamorelin, a single dose of Ipamorelin (1mg/kg) or GHRP-6 (20μg/kg) can reduce the time to first defecation. Repeated administration of Ipamorelin (0.1 or 1mg/kg) can significantly increase the cumulative fecal output, food intake, and weight gain [4]. 3. Effects on insulin secretion Ipamorelin can stimulate insulin secretion in pancreatic tissue fragments of normal and diabetic rats. The increase in insulin secretion induced by Ipamorelin can be significantly inhibited by diltiazem, yohimbine, propranolol, or a combination of atropine, propranolol, and yohimbine. In diabetic rats, atropine can significantly reduce the insulin secretion induced by Ipamorelin, but this effect is not observed in normal rats. This indicates that Ipamorelin stimulates insulin release through the calcium channel and adrenergic receptor pathways[5]. 4. Alleviating pain In experimental models of non-inflammatory visceral hypersensitivity and somatic mechanical allodynia, Ipamorelin, as a peripherally restricted ghrelin receptor agonist, can significantly reduce colonic hypersensitivity and somatic allodynia. Its mechanism of action is mediated by the ghrelin receptor, and this antinociceptive effect can be blocked by the ghrelin receptor antagonist H0900[6]. Shows the effect of ipamorelin on insulin secretion from pancreatic tissue fragments of normal and diabetic rats. Source:PubMed[5] What are the applications of Ipamorelin? 1. Promoting the release of growth hormone Ipamorelin can stimulate the release of growth hormone from the hypothalamus and pituitary gland. Growth hormone plays an important role in the human body, including promoting protein synthesis, cell proliferation, and tissue repair. Therefore, Ipamorelin can be used to treat growth hormone deficiency or other diseases related to growth hormone insufficiency[7]. 2. Improving gastrointestinal function Accelerating gastric emptying: In rodent models, Ipamorelin accelerates gastric emptying in models of postoperative ileus through a mechanism mediated by the activation of the growth hormone releasing peptide receptor, involving cholinergic excitatory neurons[1]. Abdominal surgery leads to delayed gastric emptying, and administration of Ipamorelin can significantly reduce the proportion of residual food in the stomach, thereby improving gastric motility. Promoting gastrointestinal peristalsis: In rodent models of postoperative ileus, Ipamorelin may improve the symptoms of patients. For example, in a rat model, Ipamorelin can reduce the time to first defecation after surgery, increase fecal output, food intake, and weight gain[4]. Repeated administration of Ipamorelin can significantly increase the cumulative fecal output, food intake, and weight gain, indicating its positive regulatory effect on gastrointestinal function. 3. Relieving pain Relieving visceral and somatic pain: Research shows that Ipamorelin, as a growth hormone releasing peptide receptor agonist, has antinociceptive properties. In experimental models without colonic epithelial inflammation, Ipamorelin can significantly reduce non-inflammatory visceral hypersensitivity and somatic mechanical allodynia[6]. Its mechanism of action may be mediated by the growth hormone releasing peptide receptor, participating in the regulation of visceral and somatic hypersensitivity, providing a potential new method for the treatment of acute visceral and somatic pain. What are the research progress of Ipamorelin in the treatment of growth hormone deficiency? Growth hormone deficiency is a disease caused by insufficient secretion of growth hormone from the anterior pituitary gland, which can affect the growth and development of children and the body metabolism of adults. In recent years, Ipamorelin, as a growth hormone secretagogue, has attracted widespread attention in the treatment of growth hormone deficiency. The following is the relevant research progress of Ipamorelin in the treatment of growth hormone deficiency. 1. The stimulating effect of Ipamorelin on growth hormone secretion Ipamorelin can stimulate the secretion of growth hormone. Research shows that Ipamorelin can act synergistically with growth hormone releasing hormone (GHRH) to enhance the release of growth hormone[8]. In animal experiments, after 21 days of chronic treatment with Ipamorelin in young female rats, compared with the control group, the basal growth hormone release in the monolayer culture of pituitary cells increased. At the same time, Ipamorelin and GHRH can stimulate the release of growth hormone from cultured pituitary cells in vitro. However, in the GHRH pretreatment group, the subsequent growth hormone response to stimulation was not enhanced, while in the Ipamorelin pretreatment group, there was no such desensitization phenomenon, indicating that Ipamorelin does not lead to desensitization of the growth hormone response in young female rats[8]. 2. The effect of Ipamorelin on weight gain Chronic administration of Ipamorelin can effectively increase the weight of young female rats. Daily monitoring shows that the percentage of weight gain in the Ipamorelin pretreatment group and the GHRH pretreatment group is higher than that in the control group[8]. This is related to the fact that Ipamorelin stimulates the secretion of growth hormone, which in turn promotes protein synthesis and cell growth. 3. The effect of Ipamorelin on bone formation In an adult rat model, it has been found that the growth hormone secretagogue Ipamorelin can counteract the catabolic effects of glucocorticoids (GC) on skeletal muscle and bone. Compared with the group injected with GC alone, in the animals injected with both GC and Ipamorelin, the maximum tetanic tension of the calf muscle increased significantly, and the periosteal bone formation rate increased fourfold [8, 9]. This indicates that Ipamorelin has a positive effect on maintaining muscle strength and promoting bone formation, and may help prevent complications such as osteoporosis in patients with growth hormone deficiency. 4. The effect of Ipamorelin on gastrointestinal function As a selective growth hormone-releasing hormone agonist and growth hormone-releasing peptide receptor agonist, Ipamorelin demonstrated therapeutic efficacy in a mouse model of postoperative intestinal paralysis. Single administration of Ipamorelin or growth hormone-releasing peptide (GHRP)-6 shortened the time to the first postoperative bowel movement, but had no effect on cumulative fecal output, food intake, or weight gain. Ipamorelin increases cumulative fecal output, food intake, and weight gain. This suggests that Ipamorelin may have a certain role in improving gastrointestinal function and may help improve digestive and absorptive function in patients with growth hormone deficiency.[4]. In summary, as a selective growth hormone secretion promoter, Ipamorelin efficiently stimulates the release of growth hormone by activating the growth hormone-releasing peptide receptor (GHS receptor), without significantly affecting the levels of adrenocorticotropic hormone (ACTH) and cortisol. Its functions include promoting growth hormone secretion, regulating gastrointestinal motility, and alleviating pain. Its high selectivity and multi-target characteristics confer clinical application potential, making it suitable for use in conditions such as growth hormone deficiency, postoperative intestinal obstruction, and pain management. Relevant Citations [1] Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C. Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus. Journal of experimental pharmacology 2012; 4: 149-55.DOI:10.2147/JEP.S35396. [2] Beck DE, Sweeney WB, McCarter MD. Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. INT J COLORECTAL DIS 2014; 29(12): 1527-34.DOI:10.1007/s00384-014-2030-8. [3] Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. EUR J ENDOCRINOL 1998; 139(5): 552-61.DOI:10.1530/eje.0.1390552. [4] Venkova K, Mann W, Nelson R, Greenwood-Van Meerveld B. Efficacy of Ipamorelin, a Novel Ghrelin Mimetic, in a Rodent Model of Postoperative Ileus. J PHARMACOL EXP THER 2009; 329(3): 1110-6.DOI:10.1124/jpet.108.149211. [5] Adeghate EA, Ponery AS. Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats. Neuro endocrinology letters 2004; 25 6: 403-6. [6] N Mohammadi E, Louwies T, Pietra C, Northrup SR, Greenwood-Van Meerveld B. Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics. J Exp Pharmacol 2020; 12: 267-74.DOI:10.2147/JEP.S249747. [7] Papak M. Ipamorelin - struktura i funkcija.; 2016. https://www.semanticscholar.org/paper/IpamorelinstrukturaifunkcijaPapak/6f1496dcedd60ec60a90be4c1f317a8bad7efb08 [8] Jiménez-Reina L, Cañete R, de la Torre MJ, Bernal G. Influence of chronic treatment with the growth hormone secretagogue Ipamorelin, in young female rats:: somatotroph response in vitro. HISTOL HISTOPATHOL 2002; 17(3): 707-14. DOI: 10.14670/HH-17.707 [9] Andersen NB, F KMO, Johansen PB, Andreassen TT, Rtoft GO, Oxlund H. The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats. Growth hormone \& IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2001; 11 5: 266-72.DOI:10.1054/GHIR.2001.0239. For Research Use OnlyThis compound is provided exclusively for in vitro laboratory research. It is not intended for human or animal consumption, diagnosis, treatment, or medical use. Not for dietary, cosmetic, or veterinary purposes. This product has not been evaluated by the U.S. Food and Drug Administration or any other regulatory authority. DisclaimerAll information is for educational purposes only. Humatide makes no claims regarding efficacy or safety. Purchasers are responsible for ensuring proper handling and use in compliance with all applicable laws and regulations. Terms of SaleBy purchasing from Humatide, you confirm that you are a qualified researcher with the knowledge and facilities to safely handle and store research chemicals. All sales are final. Humatide assumes no liability for misuse, misrepresentation, or unintended consequences arising from the use of this product. Show more