Joint Support Nutrients combines the preeminent joint support ingredient, glucosamine, with other nutrients and botanicals that also support joint health. Glucosamine demonstrates significant joint support, as evidenced by numerous clinical studies. Methyl sulfonyl methane (MSM) also helps support joint integrity and mobility. Bromelain promotes healing after minor injury.*Thorne's Meriva® ingredient – curcumin bound to phospholipids – and boswellia both exert an antioxidant effect and help maintain a healthy cytokine balance (for a normal inflammatory response) in the joints and muscles. Joint Support Nutrients combine all of these ingredients in a single comprehensive joint support supplement.*Joint Support Nutrients is a comprehensive joint support formula that goes beyond simple glucosamine supplementation. This formula supplies 1,500 mg of glucosamine sulfate (suggested use – four capsules twice daily), the amount used in the majority of studies – in combination with other joint-supporting nutrients and botanicals.*Glucosamine provides significant joint support, as evidenced by numerous clinical studies. Methyl sulfonyl methane (MSM) – also known as dimethyl sulfone and methyl sulfone – is an organic, sulfur-containing compound that occurs naturally in a variety of plants and provides additional joint support.*In a study of healthy adult subjects with mild knee soreness, bromelain supplementation resulted in significant improvement with both 200-mg and 400-mg daily use.1 Joint mobility was also improved.*Curcumin, the principal polyphenol in the Asian spice turmeric, exerts an antioxidant effect. Curcumin phytosome (Meriva®), a compound that contains curcumin and phosphatidylcholine, has significantly better absorption than ordinary curcumin and helps maintain a healthy cytokine balance throughout the body.*Boswellia appears to inhibit the activity of the lipoxygenase enzymes, thus promoting a healthy cytokine balance throughout the body. A study of curcumin and boswellia found significant support of normal joint mobility in the group taking the botanical formula.2*This product has been third-party tested and certified to verify what's in the package matches what's on the label and to confirm it contains no unsafe levels of contaminants, such as heavy metals, pesticides, and microorganisms.References Walker AF, et al. Phytomedicine 2002;9:681-686. Kizhakkedath R. Mol Med Rep 2013;8:1542-1548. Suggested Use:Take 4 capsules one to two times daily or as recommended by your health-care practitioner.Warnings:ALLERGY WARNINGS This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.Joint Support Nutrients contains ingredients derived from shellfish (glucosamine sulfate = crab and/or shrimp).PREGNANCYIf pregnant, consult your health-care practitioner before using this product.INTERACTIONSCurcumin has been shown to reduce the therapeutic efficacy of cyclophosphamide (Cytoxan) in animal studies. In vitro research revealed that curcumin decreased camptothecin-induced death of cultured breast cancer cells. Curcumin might also interfere with the absorption and efficacy of the chemotherapy drug irinotecan, used to treat colon cancer. The concurrent use of curcumin with these agents should be avoided.Because bromelain has fibrinolytic effects, potentially inhibiting blood clotting, Joint Support Nutrients should be used with caution or avoided in individuals on anticoagulant therapy.ADDITIONAL WARNINGSIt is not recommended to remove the Joint Support Nutrients powder from the capsule to take orally, as it can be irritating to the oral mucosa.
