Douglas Laboratories Klean-D 5000 IU Klean-D™ contains 5,000 IU of natural vitamin D3 per tablet. Vitamin D supplementation may help support immune health, musculoskeletal strength, and physical performance in athletes. Ingredients Serving Size: 1 Tablet Amount/Serving Vitamin D3 (as cholecalciferol) 125 mcg (5,000 IU) Other Ingredients: Microcrystalline cellulose, calcium carbonate, croscarmellose sodium, stearic acid, coating (Hypromellose, glycerin), silica, and vegetable stearate. Gluten-Free, Non-GMO, Vegetarian, NSF Certified Sport Suggested Use As a dietary supplement, adults take 1 tablet daily with a meal, or as directed by a trainer, coach, or health professional. Warning: If you are pregnant, nursing, have any health condition, or are taking any medication, consult your health professional before using this product. Use only if safety seal is intact. Keep out of reach of children. People consuming more than 50 mcg (2,000 IU) per day should have their vitamin D blood levels monitored by a health professional. Storage: Store in a cool, dry place, away from direct light. Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. More Info. Vitamin D, also known as the “sunshine vitamin,” is an essential vitamin that plays many important roles in the proper functioning of the body. Though classified as a vitamin, vitamin D is actually a key regulatory hormone for multiple physiological processes. It is estimated that 1 billion people, including the elderly, young adults, athletes, and children, are vitamin D deficient or insufficient. The main cause of vitamin D deficiency in the athletic population is the direct result of decreased ultraviolet B (UVB) radiation absorption into the skin, which especially affects indoor athletes and those who live and train in northern latitudes. Adequate vitamin D status is essential for ensuring normal calcium absorption and maintenance of healthy plasma calcium levels. Besides bone support, vitamin D has many other roles in the body, including modulation of cell growth, neuromuscular and immune function, and inflammatory support. Clinical research has shown there is a positive association between Vitamin D 25(OH)D serum concentrations, lower extremity function, proximal muscle strength and physical performance. Vitamin D deficiency is associated with diffuse muscle pain, muscle weakness predominantly in the proximal muscle groups, and a reduction in performance speed. A serum 25-hydroxyvitamin D level below 50 nmol/l has been associated with increased body sway and a level below 30 nmol/l with decreased muscle strength. Based on the study by Barker et al, pre-exercise serum 25(OH)D concentrations could influence the recovery of skeletal muscle strength after an acute bout of intense exercise. Numerous scientists now feel that supplementation with vitamin D at levels greater than previously thought necessary is critical to helping maintain healthy bone remodeling and healthy vitamin D plasma levels. A committee of the Institute of Medicine reviewed the data on vitamin D needs and concluded that persons are at risk of vitamin D deficiency at serum 25(OH)D concentrations