Klotho Polyclonal Antibody Sizes: 50µl, 100µl Catalogue Numbers: BS90774-50, BS90774-100 Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Swiss-Prot: Q9UEF7(Human) O35082(Mouse) Host: Rabbit Reactivity: Human, Mouse Applications: WB, IHC All Applications: WB:1:500-1:2,000 IHC:1:50-1:200 Background: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. Purification and Purity: ProA affinity purified Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Specificity: Klotho polyclonal antibody detects endogenous levels of Klotho protein. Immunogen: Recombinant protein Conjugate: Unconjugated Modification: Unmodified Note: For research use only, not for use in diagnostic procedure. Extra Notes: Western blot analysis of Klotho on human serum lysate using anti-Klotho antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Klotho antibody. Counter stained with hematoxylin.
