Citrulline is a non-essential amino acid, but its usefulness to the athlete is quite remarkable. This amino acid is a precursor of arginine, but seems much better assimilated than the latter by the intestines. It significantly increases vasodilation by stimulating the production of nitric oxide.Recommended use or purpose: Helps to decrease cognitive fatigue due to physically stressful situations (e.g. extended wakefulness, exposure to cold, excessive noise) Recommended dose: Adults. Take 1 portion daily. Take up to one hour before, or during periods of physical stress DURATION OF USE: For occasional use only. Citrulline is a non-essential amino acid, but its usefulness to the athlete is quite remarkable. MEDICINAL INGREDIENTS (per serving of 3150 mg): Citrulline Malate ... 3000 mg Providing 1650 mg of L-Citrulline L-Leucine ... 150 mg