Support your brain health with the trace mineral lithium. Lithium is an alkali mineral salt that we are most familiar with incorporated into rechargeable batteries found in our laptops, phones and electric vehicles. The truth is that lithium is a naturally occurring mineral, sometimes found in mineral waters, that has profound effects on our brain and overall health. High dose lithium carbonate or citrate have been used by doctors to treat brain disorders such as bipolar and mania. Such high doses of 600-1200 mg daily have often caused heart arrhythmias, muscle tremors, hypercalcemia, weight gain and other negative effects. Lithium bound to oratic acid is called lithium orotate. Many people respond better to it than the other forms, possibly because the dosage doesn't need to be nearly as high; Andean folk in Northern Argentina consume 2-30mg daily in their drinking water (Concha, et al 2010). BENEFITS OF LITHIUM: Mood support via regulating the release of neurotransmitters dopamine, noradrenaline and serotonin Reproductive support by its pivotal role in early fetal development (Schrauzer, et al 2002) Cardiovascular support by activating the PI3K/Akt pathway which regulates GSK3 activity, consequently increasing SERCA function, a calcium handling protein. In English this means that cardiac contractile function and overall cardiac muscle function is improved (Hamstra, et al 2020). Maintaining healthy vasculature, supporting oxygen delivery and metabolite transport to and form various organs (Choi, et al 2010; Bosche, et al 2016). Bone health support, increasing bone formation and mass (Kurgan, et al 2019; Clément-Lacroix, et al 2005). Staving off sarcopenia, age-related decline in muscle mass and strength (Kurgan, et al 2019). Supports the pancreas, improves hyperglycemia and glucose removal (Zhang, et al 2021; Jung, et al 2017) Neuroprotective effects via modulating homeostatic mechanisms in the brain (autophagy, mitochondrial function, neurotrophic response) staving off Alzheimer's, ALS, and Parkinson's (Forlenza, et al 2014). Lowering inflammation and oxidative stress (Khairova, et al 2012) Protects against lipid peroxidation (Shao, et al 2005) Every year we discover more and more benefits of this potent mineral. Much of the benefits elucidated in the studies cited above are a result of inhibiting GSK3, Glycogen Synthase Kinase-3, an enzyme involved in glycogen metabolism. Elevated levels have been implicated in type 2 diabetes and obesity. GSK3 inhibitors have been used to normalize blood glucose levels, combat various neurodegenerative and neuro-inflammatory disorders, combat depression and anxiety, increase neurogenesis, and regulate the circadian rhythm. Lithium is a natural GSK3 inhibitor along with zinc and melatonin. SUGGESTED USAGE: Take one capsule once per day with or without a meal. STUDIES: High-level exposure to lithium, boron, cesium, and arsenic via drinking water in the Andes of northern Argentina Lithium: occurrence, dietary intakes, nutritional essentiality Low-dose lithium feeding increases the SERCA2a-to-phospholamban ratio, improving SERCA function in murine left ventricles Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM expression in ApoE-deficient mice Low-Dose Lithium Stabilizes Human Endothelial Barrier by Decreasing MLC Phosphorylation and Universally Augments Cholinergic Vasorelaxation Capacity in a Direct Manner Low dose lithium supplementation activates Wnt/β-catenin signalling and increases bone OPG/RANKL ratio in mice Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes Effect of Lithium on the Mechanism of Glucose Transport in Skeletal Muscles Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders Effects of lithium on oxidative stress parameters in healthy subjects Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cells
