MC4-R (E315) Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: BS2811-50, BS2811-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: MC4 receptor is the fourth member of the five known melanocortin receptors (MCRs) belonging to the rhodopsin-like family of G protein-coupled receptors (GPCRs). These five MCRs form a unique family of GPCRs, marked by their unusually short coding sequence and the absence of highly conserved amino acid residues or motifs common to most GPCRs. All MCRs signal through the cyclic adenosine 3', 5'-monophosphate (cAMP) pathway. With the exception of MC2R, all MCRs are activated by both adrenocorticotropin (ACTH) and melanocyte-stimμlating hormones (MSHs and mainly alpha-MSH). The MC4R receptor is expressed primarily in the brain, and unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes. Genetic studies of mice and humans have established a critical role of MC4 Receptor in appetite regμlation. Heterozygous mutations in MC4 Receptor account for 1-6% of severe cases of human obesity. Category: Primary Antibody Reactivity: Human, Mouse, Rat Host: Rabbit Applications: IHC Alternate Names: Melanocortin receptor 4, MC4-R, MC4R Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: Synthetic peptide, corresponding to amino acids 300-350 of Human MC4-R. Dilution: IHC: 1:50~1:200 Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Specificity: MC4-R (E315) polyclonal antibody detects endogenous levels of MC4-R protein. Molecular Weight: ~ 37 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: P32245 Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Research Use Only
