Each regimen includes 60-days of treatment. Melasma is the reaction of the skin to sun and hormones. It is worsened in pregnancy and with oral contraceptive pills. Melasma is formed with layers of pigment that sink into the deep levels of the skin. Sun avoidance and heavy protection are needed and it often recurs if it is not treated and prevented. Doctor's recommendations are to start cleansing with only water in the morning, apply the AM medication followed by one to two coats of an SPF 50+ broad spectrum sunscreen. In the evening cleanse with a brightening cleanser, apply the PM medication followed by a deeply hydrating moisturizer. Active ingredients your prescription may include niacinamide, hydroquinone, tranexamic acid, azaleic acid, vitamin C, tretinoin, kojic acid Instructions:AM BottleApply a SPF 50+ sunscreen, reapply every 2 hours - Apply AM medication - Apply moisturizerPM BottleApply PM medication - Apply a moisturizer Why Derm to Door? Free, fast shipping with automatic refills. Pause or cancel anytime FDA approved medication & affordable prices Licensed Dermatologist, Fast results