Ortho Molecular Melatonin 10 mg Endocrine Health Melatonin is a hormone produced by the pineal gland and plays a key role in regulating the body’s circadian rhythms, endocrine secretions, and sleep patterns. It also plays an essential role in maintaining normal inflammatory balance and supports the body with strong antioxidant activity. This formulation is available as a 10 mg tablet for flexible dosing. Melatonin is primarily produced by the pineal gland but also in the bone marrow, platelets, GI tract, eyes, skin, and lymphocytes. Its chemical precursor is serotonin, a neurotransmitter derived from tryptophan. Serotonin must be acetylated and methylated to form melatonin. Synthesis and production of melatonin are affected by light exposure to the eyes; serum concentrations of melatonin are typically low during the daytime hours and increase as night falls. Since it has important effects on circadian rhythms, melatonin has also been reported to have significant effects on reproduction in addition to sleep-wake cycles and antioxidant function. Key Benefits and Features: Helps Regulate the Body’s Circadian Rhythm Promotes Immune Cell Activity Provides Antioxidant Activity Directly and Indirectly Maintains Normal Inflammatory Balance Ingredients Serving Size: 1 Tablet Amount/Serving Melatonin 10 mg Other Ingredients: Mannitol, Microcrystalline Cellulose, Natural Flavors, Fruit and Vegetable Juice (for color), Luo Han Guo Extract (Fruit), Stearic Acid, Silicon Dioxide, and Citric Acid. Does Not Contain: Gluten, yeast, synthetic colors, or artificial flavors. Suggested Use Take 1 tablet per day or as recommended by your health care professional. Warning: If you are pregnant or nursing, consult your physician before taking this product. Keep out of the reach of children. Storage: Keep tightly closed in a cool, dry place. More Info. DeficiencyNighttime secretion of melatonin peaks between one and three years of age, and nocturnal levels naturally decline with age. Light inhibits melatonin secretion, so when the body is not exposed to an appropriate amount of environmental light, melatonin levels decrease. Research suggests that melatonin supplementation supports healthy sleep patterns in certain individuals, such as the elderly, individuals with nighttime working hours, or people traveling across time zones. Low levels of melatonin in the body are often associated with occasional sleep disturbances that may impact overall health. Sleep SupportMelatonin supports the quality of healthy sleep as it relates to falling asleep, sleep efficiency, and awakening. In adults, studies have shown that doses between 0.3-75 mg have a positive effect on increasing total sleep time and reducing the time it takes to fall asleep. Immune SupportMelatonin has been shown to be a powerful antioxidant and antioxidant inducer. It supports glutathione production and stimulates intracellular antioxidant enzyme production, including superoxide dismutase, glutathione peroxidase, and glutathione reductase. It has also been found to scavenge free radicals and promote cytokine balance, which helps maintain normal inflammatory balance. Specifically, melatonin has been shown to have an inhibitory effect on the NLRP3 inflammasome. Melatonin is also able to pass through the lipid part of low-density lipoprotein (LDL) and act as an antioxidant in cells. It has been found to maintain healthy blood pressure levels, and improves measures of quality of life such as mental health, vitality, and temporarily relieves body aches in young adults.
