Melatonin 3 mg 180 Sublingual Tablets Benefits Sublingual tablets provide fast and superior melatonin absorption, bypassing liver and gastrointestinal metabolism - pharmacokinetic studies indicate that 30 to 60% of an oral dose of melatonin is metabolized via the liver1 and overall gastrointestinal absorption is variable2,3 3 mg strength is optimal for those who require basic sleep support or are trying melatonin for the first time Derived from non-animal sources Refreshing, natural peppermint flavour Non-habit forming Feature Summary Sleep is a vital part of health and many of us are not getting enough. The 2002 Canadian Community Health Survey found about 1 in 7 adults has difficulty falling asleep or staying asleep. Insomnia affects 1 in 3 seniors and is 40% more common in women. Changes in sleeping patterns are largely reflective of our circadian rhythms, which are guided by the pineal hormone, melatonin. Melatonin is known to decline as we age, which accounts for a number of the sleep changes we see throughout life. Additionally, jet lag and shift work can significantly alter circadian rhythms and thusmelatonin secretion. Melatonin has shown clinical benefit for inducing sleep or adjusting sleep cycles, reducing sleep onset latency and improving perceived quality of sleep, without impairing daytime psychomotor performance. In fact, supplemental melatonin and bright light therapy are considered standard medical treatment for cases of jet lag, shift work, age-related insomnia, delayed sleep-phase disorder, advanced sleep-phase disorder, and non-24-hour sleep-wake disorder. Chronic sleep disturbance is a risk factor for premature aging, diabetes, obesity, cardiovascular disease and certain cancers, demonstrating just how important it is to maintain normal melatonin levels to enhance sleep quality. Medicinal Ingredients Each Tablet Contains: Melatonin (vegetarian source) 3 mg Non-Medicinal Ingredients Lactose monohydrate, microcrystalline cellulose, natural peppermint flavour, croscarmellose sodium, vegetable grade magnesium stearate (lubricant). Dosage Recommended Adult Dose: Do not drive or use machinery for 5 hours after taking melatonin. Dissolve 1 tablet under the tongue at bedtime once per day or as directed by a health care practitioner. Consult a health care practitioner for use beyond 4 weeks. Warnings Consumption with alcohol, other medications or natural health products with sedative properties is not recommended. Consult a health care practitioner prior to use if you have one of the following conditions: asthma, cardiovascular disease, chronic kidney disease, depression, diabetes or hypoglycaemia, hormonal disorder, immune system disease, liver disease, migraine, or seizure disorders, or if you are taking one of the following medications: anticoagulant, anticonvulsant, blood pressure medications, immunosuppressive medications, sedative, hypnotic or psychotropic medications, or steroids. Do not use if you are pregnant or breastfeeding. Mild gastrointestinal symptoms (nausea, vomiting, or cramping) and rare allergic reactions have been known to occur, in which case discontinue use. If symptoms persist continuously for more than 4 weeks (chronic insomnia), consult your health care practitioner. Keep out of reach of children. Allergens Contains no artificial colours, preservatives, or sweeteners; no starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place. Contraindications Do not use if you are taking immunosuppressive drugs and/or if you are pregnant or breastfeeding.Do not drive or use machinery for 5 hours after taking melatonin. Drug Interactions Melatonin may impair glucose utilization and increase insulin resistance in diabetic patients. However, the clinical significance of this effect on diabetics is unknown. Contraceptive drugs can increase endogenous melatonin levels. Theoretically, this may increase the effects and adverse effects of oral melatonin use. Fluvoxamine significantly inhibits the elimination of melatonin, which some researchers believe could be helpful in the treatment of refractive insomnia. However, this interaction may also cause excessive unwanted drowsiness and other adverse effects. Melatonin production and release may be inhibited by beta-blockers16 and non-steroidal anti-inflammatory drugs.
