LIPO Melatonin™ promotes high-quality sleep and balances your “body clock.” Benefits may include improvement of sleep onset, sleep pattern and a decrease in cortisol levels. Offering an advanced liposomal source of the natural hormone—N-acetyl-5-methoxytryptamine—LIPO Melatonin™ is expertly designed to overcome low absorption issues. Balance Cortisol Levels Melatonin is mainly known for its ability to regulate the sleep-wake cycle (circadian rhythm or chronobiology) via its release from the pineal gland. Studies demonstrate that melatonin decreases sleep onset latency, increases total sleep time and improves overall sleep quality. In addition to improving sleep, melatonin is also involved in managing immune function, blood pressure and cortisol levels. Only 15% Absorption in Standard Melatonin Supplements Oral melatonin has an absolute bioavailability of about 15 percent. So, if you take a 4 mg melatonin pill, your body is only absorbing around 0.6 mg. Our encapsulation process in liposomes protects melatonin from premature degradation while enhancing its intestinal absorption. The absorption of non-liposomal oral melatonin is minimal due to high first-pass clearance in the liver and low absorption in the gastrointestinal tract. 4 Liposomes extend the time a supplement is available in the bloodstream, but the peak availability is between 2 and 4 hours, which is while you are sleeping. However, some is absorbed well before the 2 hours and actually may work faster than standard Melatonin. This study found Liposomal Melatonin decreased the time to sleep (Sleep latency – SL). from 18 minutes to 10 minutes. “A significant difference in SL was observed (10.8 ± 5 vs. 18.1 ± 13.4 min, p-value = 0.002)… Our study confirmed the efficacy and safety of melatonin administration in sleep induction. Nonetheless, liposomal melatonin presents a greater bioavailability, ensuring a faster effect and allowing lower dosages.”
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