Meso Scale Discovery MULTI-ARRAY & MULTI-SPOT Immunoassay Microplates – 96-Well / 384-Well SECTOR & QuickPlex Formats, Integrated Carbon-Ink Electrodes, Electrochemiluminescence (ECL) Technology (Model Family: L25XA-1 / L11XA-1 / L15XA Series) Expiration Date 11-2011 The Meso Scale Discovery (MSD) L25XA-1 and L11XA-1 series (often cross-referenced within the broader L15XA standard binding portfolio) are instrument-grade, high-performance multi-array microplates precision-engineered for advanced electrochemiluminescence (ECL) immunoassays. Available in both standard 96-well and high-density 384-well configurations matching ANSI/SLAS dimensions, these microplates serve as the foundational execution matrix for MSD SECTOR Imagers and MESO QuickPlex readers. Featuring a proprietary uncoated hydrophobic "Standard Bind" surface, they are optimized for the passive, high-capacity adsorption of custom capture antibodies, structural proteins, and complex biological fractions. Integrated directly into the floor of every well is a screen-printed carbon-ink electrode that delivers precise electrical stimulation to trigger localized light emission from SULFO-TAG biomarkers, achieving up to a 5-log linear dynamic range with minimal sample volumes. Technical Performance and Design Electrochemiluminescence (ECL) Activation: Outfitted with integrated carbon-ink working electrodes at the baseline of each well. Applying voltage stimulates light emission from bound SULFO-TAG labels, physically decoupling the excitation mechanism from the optical sensor to provide a virtually background-free detection window. Standard Bind Hydrophobic Surface: Engineered with a specialized, uncoated hydrophobic polymer surface. This matrix provides robust, high-affinity passive adsorption parameters for structural proteins and hydrophobic antibodies, making it exceptional for custom "homebrew" assay development. Enhanced Multi-Log Dynamic Range: Delivers a linear dynamic range stretching over 3 to 5 logs. This expansive coverage allows labs to confidently quantitate highly concentrated and low-abundance analytes in the same run, minimizing tedious multiple sample dilutions. Low Volumetric Sample Conservation: Highly efficient surface kinetics permit reliable target capture using low sample volumes (typically 25 µL or less), preserving precious clinical sample lines like pediatric plasma, cerebrospinal fluid, and murine serum. Product Specifications Catalog Numbers / Model Subtypes: L25XA-1 / L11XA-1 (Associated with the L15XA / L15XB Standard & High Bind microplate matrix) Manufacturer / Brand: Meso Scale Discovery (MSD) / Meso Scale Diagnostics, LLC Plate Footprint Formats: Standard 96-Well Matrix (9 mm center-to-center spacing) / 384-Well Matrix (4.5 mm center-to-center spacing) Spot Configuration Profile: 1-Spot MULTI-ARRAY target interface (Upgradable to multi-spot arrays) Detection Methodology: Electrochemiluminescence (ECL) Material Composition: Premium Polystyrene plate chassis embedded with pure Carbon-Ink base electrodes Surface Binding Hydrophobicity: Uncoated Standard Bind (Hydrophobic matrix configuration) Reader Platform Compatibility: 96-well configurations interface with the MESO QuickPlex SQ 120 and SECTOR Imagers (S 600, Imager 2400/6000); 384-well arrays are calibrated exclusively for simultaneous camera sector capture on high-throughput SECTOR series imagers Key Benefits and Applications Custom Assay Development ("Homebrew"): The primary blank-slate plate format utilized by pharmaceutical R&D labs to coat custom capture proteins, converting traditional ELISAs into rapid, high-sensitivity ECL multiplex assays. Pharmacokinetic (PK) & Immunogenicity Profiling: Widely deployed to monitor drug toxicity profiles, vaccine glycoprotein reactions, neutralizing antibodies, and complex serum biomarkers across long-term pre-clinical animal models. Crude Biological Matrix Compatibility: The carbon electrode surface resists fouling from unpurified cellular debris, lysing agents, and lipids, allowing researchers to spin raw tissue culture supernatants without extensive sample preparation steps. High-Throughput Robotic Compatibility: Molded with highly rigid side-walls and industry-standard skirt tolerances, enabling error-free loading, barcoding, and tracking by automated multi-plate stackers and liquid-handling decks. All product names, logos, and brands are property of their respective owners.
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