Metabolic Maintenance DIM Complex 100mg is a comprehensive estrogen metabolism support formula combining DIM (Diindolylmethane) with synergistic cofactors that support healthy estrogen metabolism — promoting the formation of protective 2-hydroxy estrogen metabolites over the inflammatory 16-alpha and 4-hydroxy pathways. 60 capsules. Metabolic Maintenance is a physician-grade supplement manufacturer founded in 1984, formulating products exclusively with pharmaceutical-grade raw materials in clean, excipient-free capsules — no fillers, binders, colors, or artificial additives. Available at Beauty Riche with same-day shipping.DIM (Diindolylmethane, 100mg) is produced in the stomach from I3C (Indole-3-Carbinol) in cruciferous vegetables — it upregulates CYP1A1 and CYP1A2 enzymes that favor 2-hydroxylation (the protective pathway) over 4-hydroxylation and 16-alpha-hydroxylation (the pathways associated with estrogen-sensitive conditions). N-Acetylcysteine (100mg) supports glutathione for Phase II conjugation of estrogen metabolites. Calcium-D-Glucarate (100mg) inhibits beta-glucuronidase — preventing the intestinal deconjugation and reabsorption of estrogens that have been processed for elimination. Lemon Bioflavonoids (100mg) provide Phase II support. Cofactors include active folate (L-5-MTHF, 200mcg), Methylcobalamin B12, and B6 (P-5-P) for methylation of estrogen metabolites. Vitamin C and E provide antioxidant support against reactive estrogen quinone metabolites.