Metabolic Maintenance L-Methylfolate 15mg is the highest-dose L-methylfolate formula in the Metabolic Maintenance line — delivering 15mg of active L-5-MTHF per capsule for high-demand clinical methylfolate applications. 60 capsules. Metabolic Maintenance is a physician-grade supplement manufacturer founded in 1984, formulating products exclusively with pharmaceutical-grade raw materials in clean, excipient-free capsules — no fillers, binders, colors, or artificial additives. Available at Beauty Riche with same-day shipping.At 15mg, this is a physician-directed therapeutic dose used in: severe MTHFR compound heterozygous or homozygous presentations; treatment-resistant depression where L-methylfolate adjunctive therapy has the strongest evidence base (clinical trials using 15mg L-methylfolate as adjunct to SSRIs in MTHFR-positive patients with depression); homocystinuria; and high-demand methylation support protocols. Excipient-free, single-ingredient. Use under physician supervision at this dose.