Metabolic Maintenance SAMe (S-Adenosylmethionine) 200mg delivers the universal methyl donor at a clinically meaningful dose in a shelf-stable, room-temperature-stable capsule formula — alongside key methyl cofactors (Methylcobalamin B12, L-5-MTHF, Pyridoxal-5'-Phosphate B6) that support the methylation cycle SAMe participates in. 60 capsules. Metabolic Maintenance is a physician-grade supplement manufacturer founded in 1984, formulating products exclusively with pharmaceutical-grade raw materials in clean, excipient-free capsules — no fillers, binders, colors, or artificial additives. Available at Beauty Riche with same-day shipping.SAMe is a metabolite of methionine that serves as the primary methyl donor in over 100 transmethylation reactions throughout the body — including synthesis of neurotransmitters (serotonin, dopamine, norepinephrine), phospholipids for cell membranes, glutathione (the master antioxidant), and creatine. Low SAMe levels are associated with depression, liver disease, and osteoarthritis. The co-factors protect against homocysteine accumulation from SAMe's methylation reactions. Metabolic Maintenance's proprietary shelf-stable formulation avoids the shellacs, waxes, and phthalate-containing coatings of conventional SAMe tablets. GMP-compliant, excipient-free.