Methyl-beta-cyclodextrin Solution 10% (w/v) Catalog # K1010005C Lot # Batch Dependent Expiration Batch Dependent Amount 25 mL Concentration 10% (w/v) Supplied as Solution Applications Solubility enhancement, molecular assemblies, organic synthesis Storage 2–8°C Keywords Methyl-β-cyclodextrin, Methyl-b-cyclodextrin Grade Biotechnology grade; ultrapure water, 0.22 µm filtered This 10% (w/v) solution of methyl-beta-cyclodextrin (MβCD) is a high-purity reagent widely used in membrane biology, drug delivery, and supramolecular chemistry. MβCD is a methylated derivative of beta-cyclodextrin that enhances the solubility of hydrophobic molecules by forming inclusion complexes. Its ability to extract cholesterol from lipid membranes has made it a critical tool in studying lipid raft dynamics and membrane protein behavior. Formulated in ultrapure water and filtered through 0.22 µm membranes, this biotechnology-grade solution is supplied in 25 mL aliquots and stored at 2–8°C. MβCD is also used in nanoparticle formulation, antiviral research, and antimicrobial enhancement. Its methylation improves aqueous solubility and reduces crystallinity, making it suitable for both analytical and preparative workflows. Key benefits: 10% (w/v) MβCD solution for cholesterol depletion and solubility enhancement Supports lipid raft studies, drug delivery, and host–guest chemistry Filtered through 0.22 µm for reproducibility and purity Packaged in ultrapure water; biotechnology grade Compatible with pharmaceutical, biochemical, and nanomedicine workflows Indication for Use: This product is for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use. References: 1: Mahammad S, Parmryd I. Cholesterol depletion using methyl-β-cyclodextrin. Methods Mol Biol. 2015;1232:91-102. 2: Cai L, Lim H, Nicholas DD, Kim Y. Bio-based Preservative using Methyl-β- cyclodextrin-Essential Oil Complexes for Wood Protection. Int J Biol Macromol. 2020 Mar 15;147:420-427. 3: Jiang Y, Liu S, Shen S, Guo H, Huang H, Wei W. Methyl-β-cyclodextrin inhibits EV-D68 virus entry by perturbing the accumulation of virus particles and ICAM-5 in lipid rafts. Antiviral Res. 2020 Apr;176:104752. 4: Mundhara N, Majumder A, Panda D. Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents. Sci Rep. 2019 May 21;9(1):7638. 5: Trapani A, Catalano A, Carocci A, Carrieri A, Mercurio A, Rosato A, Mandracchia D, Tripodo G, Schiavone BIP, Franchini C, Mesto E, Schingaro E, Corbo F. Effect of Methyl-β-Cyclodextrin on the antimicrobial activity of a new series of poorly water-soluble benzothiazoles. Carbohydr Polym. 2019 Mar 1;207:720-728. 6: Piras AM, Fabiano A, Chiellini F, Zambito Y. Methyl-β-cyclodextrin quaternary ammonium chitosan conjugate: nanoparticles vs macromolecular soluble complex. Int J Nanomedicine. 2018 Apr 24;13:2531-2541. 7: Huang J, Li C, Fan F, Liu N, Boadi F, Shen X, Hao B. Methyl-Beta- Cyclodextrin-Induced Macropinocytosis Results in Increased Infection of Sf21 Cells by Bombyx Mori Nucleopolyhedrovirus. Viruses. 2019 Oct 11;11(10):937. 8: Cesari A, Piras AM, Zambito Y, Uccello Barretta G, Balzano F. 2-Methyl-β- cyclodextrin grafted ammonium chitosan: synergistic effects of cyclodextrin host and polymer backbone in the interaction with amphiphilic prednisolone phosphate salt as revealed by NMR spectroscopy. Int J Pharm. 2020 Sep 25;587:119698. 9: Lu N, Liu Y. Structural, physicochemical, and functional (antioxidant- antimicrobial) properties of 2-O-methyl-β-cyclodextrin inclusion with hexahydro- β-acids in chitosan films. Colloids Surf B Biointerfaces. 2020 Jul;191:111002. 10: Elamin KM, Yamashita Y, Higashi T, Motoyama K, Arima H. Supramolecular Complex of Methyl-β-cyclodextrin with Adamantane-Grafted Hyaluronic Acid as a Novel Antitumor Agent. Chem Pharm Bull (Tokyo). 2018 Mar 1;66(3):277-285.
