Methyl Folate Plus™ formula provides the two metabolically bioactive forms of folate. L-5- Methylfolate and Folinic Acid together with niacinamide deliver significant support to all areas of the folate methylation process. Bioactive folate is necessary for all cells to function normally but is especially important in the nervous system and immune system. Methylfolate is an important co-factor in the production of dopamine and serotonin while also being important in mitochondrial and detoxification support. Elevated folic acid levels in the blood plasma can indicate poor methylation. This formula is also necessary for polymorphisms in the FOLR1/2, DHFR, MTHFD1, MTHFS and MTHFR genes. Methyl Folate Plus™ is designed to be used in conjunction with our Methylation Complete Dissolvable Tablets OR Neuro-Immune Stabilizer Topical Cream that provides the activating co-factors to deliver the additional tetrahydrofolate to support issues associated with methylation deficiencies.. Most often poor methylators will need additional methyl folate. Niacinamide helps support the mitochondria and supports as a cofactor for the delivery of the other ingredients. The typical indications for this product include but are not limited to: * Presence of Folate Receptor Autoantibodies *Homozygous (2 copies) MTHFR polymorphism *Development (ages 8-20) *Slow recovery from major neurological injuries *Moderate to severe autism spectrum issues *Poor recovery from traumatic injury