Folic Acid needs to be converted (methylated) in the intestines and liver to its active form 5-methyltetrahydrofolate (5-MeTHF) which is found in the blood and utilised by tissues. A very high percentage of people (60% in USA), have a genetic enzyme defect preventing them from converting Folic Acid to 5-Methyltetrahydrofolate, so 5 MTHF may be the only effective form of Folate supplementation for these people. Why Use Metabolics Methyltetrahydrofolate? Folate contributes to maternal tissue growth during pregnancy Folate contributes to normal amino acid synthesis Folate contributes to normal red blood formation Folate contributes to normal homocysteine metabolism Folate contributes to normal psychological function Folate contributes to the normal function of the immune system Folate contributes to the reduction of tiredness and fatigue Folate plays a role in the process of cell division Methyltetrahydrofolate is the methyl group donor required for the conversion of homocysteine to methionine. Folate and vitamin B12 are also required for the synthesis of methionine and S-Adenosylmethionine ( SAMe). SAMe is the common methyl donor required for the maintenance of methylation patterns in DNA that determine gene expression and DNA conformation (Zingg and Jones, 1997).5MTHF is also required for normal neurotransmitter production, such as serotonin, dopamine, melatonin, adrenalin and noradrenalin. So is a good mood support and cardiovascular support. 5 MTHF is also important as the most bioavailable form of Folic Acid during pregnancy. It plays an important role in preventing chromosome breakage and hypomethylation of DNA. If folate deficiency occurs Uracil is incorporated into DNA instead of thymine (Eto and Krumdieck, 1986; Wagner, 1995; Fenech, 2001). This can lead to mutations.
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