Cambridge University Press, 2/28/2011EAN 9780521177474, ISBN10: 0521177472Paperback, 346 pages, 22.9 x 15.2 x 2 cmLanguage: EnglishThis book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?PrefacePart I. Molecular Chaperones and the Cell Stress Response1. Chaperone functionthe orthodox view R. J. Ellis2. Intracellular disposition of mitochondrial molecular chaperonesHsp60, mHsp70, Cpn10 and TRAP-1 R. S. Gupta, T. Bowes, S. Sadacharan and B. SinghPart II. Changing Paradigms of Protein Trafficking and Protein Function3. Novel pathways of protein secretion G. Chimini and A. Rubartelli4. Moonlighting proteinsproteins with more than one function C. J. Jeffery5. Molecular chaperonesthe unorthodox view B. Henderson and A. Shamaei-TousiPart III. Molecular Chaperones as Cell Regulators6. Cell-cell signalling properties of chaperonins A. R. M. Coates7. Toll-like receptor-dependent activation of antigen presenting cells by Hsp60, Hsp70 and Gp96 R. M. Vabulas and H. Wagner8. Regulation of signal transduction by intracellular and extracellular Hsp70 A. Asea and S. Calderwood9. Hsp72 and cell signalling M. Y. Sherman10. Heat shock proteins, their cell surface receptors and effect on the immune system T. Lehner, Y. Wang, T. Whittall and L. A. Bergmei11. Molecular chaperone-Cytokine interactions at the transcriptional level A. Stephanou and D. S. LatchmanPart IV. Physiological and Pathophysiological Signals12. Heat shock protein release and naturally-occurring exogenous heat shock proteins J. Frostegård and A. G. Pockley13. Hsp27 as an anti-inflammatory Protein K. Laudanski, A. De and C. Miller-Graziano14. Bip, a negative immune regulator involved in rheumatoid arthritis V. M. Corrigal and G. S. PanayiPart V. Molecular Chaperones as Therapeutics15. Neuroendocrine aspects of the molecular chaperones ADNF and ADNP I. Gozes, I. Vulih, I. Spivak-Pohis and S. Furman16. Heat shock proteins regulate by both molecular and network cross-reactivity F. J. Quintana and I. R. Cohen17. Heat shock protein fusionsa platform for the induction of antigen-specific immunity L. Mizzen and J. Neefe18. Molecular chaperones as inducers of tumour immunity P. P. Bannerjee and Z. LiPart VI. What Does the Future Hold?19. Gazing into the crystal ballthe unfolding future of molecular chaperones L. Hightower.
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