Ortho Molecular Motility PRO Gastrointestinal Health Motility PRO is a patented combination of ginger (Zingiber officinale) and artichoke leaf extract (Cynara cardunculus L.) delivered at a clinically proven dose to restore gastric motility, improve digestion, and relieve temporary gastric discomfort. Motility in the GI tract describes the movement of food and other substances through the stomach, small intestine, large intestine, and eventually out of the body. In between meals, the migrating motor complex (MMC) is a cycle of peristaltic movement that acts as an inter-digestive housekeeper of the GI tract. The MMC facilitates transport of indigestible substances and bacteria from the stomach and small intestine into the colon, inhibiting the backward migration of colonic bacteria and an overgrowth of bacteria in the small intestine. It has been shown that motility impairment typically results in small intestinal bacterial overgrowth (SIBO). This distinctive blend of bioactives promotes contractions in the migrating motor complex, helping to restore proper motility, which ensures the steady flow of food particles and bacteria through the small intestine. In addition, it provides support for improved digestion and relief from temporary gas, bloating, and associated GI discomfort. Key Benefits and Features: Stimulates Gastric Motility and Emptying Promotes Cleansing of the Gut Supports Microbial Balance in the GI Tract Ingredients Serving Size: 1 Capsule Amount/Serving Calcium 30 mg Motility Blend (Prodigest) 320 mg Artichoke Leaf Extract (Cynara cardunculus L.) 100 mg Ginger Root Extract (Zingiber officinale Roscoe) 20 mg Other Ingredients: Microcrystalline Cellulose, Dicalcium Phosphate, Hypromellose (Natural Vegetable Capsule), Magnesium Stearate, Croscarmellose Sodium, and Silicon Dioxide. Does Not Contain: Gluten, corn, yeast, artificial colors, or flavors. Suggested Use Take 1 capsule per day on an empty stomach, or as recommended by your health care professional. Warning: If you are pregnant or nursing, consult your physician before taking this product. Keep out of the reach of children. Storage: Keep tightly closed in a cool, dry place. More Info. Artichoke Leaf Extract (Cynara cardunculus L.) Artichoke leaf (Cynara cardunculus L.) has been used for centuries to stimulate bile secretion and enhance overall liver function, which helps to restore gut motility and improve digestion. Cynaropicrin, the bitter compound found in artichoke leaf extract, along with other polyphenols, such as caffeoylquinic acids and flavonoids, has antioxidant and hepatoprotective potential and contributes to the alleviation of an impressive range of GI symptoms. In fact, in a randomized, double-blind, placebo-controlled trial, the combined supplementation with artichoke (100 mg) and ginger extract (20 mg), twice per day before lunch and dinner for 14 days, was shown to improve occasional acid indigestion. Artichoke has been said to complement the therapeutic effects of ginger as the former acts on the small intestine while the latter acts on the stomach. Ginger Root Extract (Zingiber officinale Roscoe) The therapeutic applications of ginger root (Zingiber officinale Roscoe) are vast and well-documented by both human and animal data. The therapeutic effects of ginger root reach far beyond its well-recognized role in alleviating nausea and vomiting and include its role as a carminative, spasmolytic, and digestive stimulatory agent. For example, compared with placebo, supplementation with a combination of ginger root extract (20 mg) and artichoke leaf extract (100 mg) resulted in a -24% difference in the after-meal gastric area, indicating improved gastric emptying. Additional human studies corroborate this finding, showing ginger supplementation stimulates antral contractions in the stomach and consequently accelerates gastric emptying compared to placebo. Preclinical studies suggest the active components in ginger, namely [6]-gingerol, [8]-gingerol, [10]-gingerol, and [6]-shogaol, may affect gastrointestinal motility through interaction with serotonergic receptors. Additional human data (using the same 120 mg extract described above) suggest additional gastrointestinal benefits for the combination, including improved nausea, epigastric fullness, and bloating after four weeks of daily supplementation before lunch and dinner. Ginger has also been shown to help maintain microbial balance. Supplementation with 3 g/day of ginger for four weeks has been shown to remove unwanted organisms in the gastric area and improve occasional acid indigestion with symptoms of gastric fullness, early satiety, nausea, belching, and gastric discomfort.
