MOTS-C

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MOTS-C is a naturally occurring mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of the mitochondrial genome, consisting of 16 amino acids. Supplied as a lyophilized powder in a sealed laboratory-grade glass vial. Intended for in-vitro and laboratory research applications only. Research ContextMOTS-C is studied in in-vitro and animal-model research into AMP-activated protein kinase (AMPK) signalling, a pathway central to cellular energy homeostasis. In research models it has been observed to translocate to the nucleus under metabolic-stress conditions, making it a subject of interest for investigating nuclear gene-expression and adaptive stress-response pathways. Its association with the folate cycle and de novo purine synthesis, AICAR accumulation, and subsequent AMPK activation is examined in research contexts alongside glucose-uptake, insulin-signalling, and mitochondrial-biogenesis pathways. This mitochondria-to-nucleus signalling profile makes it a subject of interest in metabolic-pathway, insulin-signalling, and cellular-longevity research. Specifications• Sequence: Validated by mass spectrometry (MS/MS)• Purity: ≥ 99% by HPLC• Form: Lyophilized powder• Molecular Weight: 2,174.4 Da• Storage: 2 – 8 °C, keep dry and away from light• Shelf Life: 24 months from manufacture date (sealed)Quality & TestingEvery batch is independently tested by a certified third-party laboratory. A Certificate of Analysis (CoA) confirming purity and identity is available for each batch. Show more