Specification Full name MTA2 rabbit polyclonal antibody Alternative names 50 μl/100 μl Reactivity rabbit polyclonal Applications WB, IHC Host Rabbit Clone type rabbit polyclonal Target Background This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. Swissprot No O94776 Gene Accession NP_004730 WB Predicted band size 75 kDa WB Positive control WB Recommended dilution 1000-5000 IHC predicted cell location Predicted cell location: Nucleus IHC positive control Positive control: Human gastric cancer IHC Recommed dilution Recommended dilution: 50-200 Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol WB PIC Description P107210-WB-1-P IHC PIC Description Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue or MTA2 antigen-treated (Neutralization experiment) using P107210(MTA2 Antibody) at dilution 1/50
