LIPO NAD+ Complete is designed to deliver the most potent dose of NAD+, NMN, NR and Trigonelline via nanoscale liposomes to increase your body’s NAD+ levels. While there is a lot of uncertainty about the pathways NAD⁺ and NAD⁺ precursors take in the body, we do know that there are differences between them, and they have affinity for different tissues. We believe the most effective protocol to increase NAD⁺ is through targeting all of these pathways. Four-In-One Capsule We provide all four in one capsule to better address all parts of the body that may benefit from restoring NAD⁺ levels. NAD+: This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications. NMN: This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes. NR: This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism. Trigonelline: Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.
