Broad spectrum antibiotic effective against most external infectionsSafe for marine and freshwaterMinimal impact on bio-filter NeoPlex™ is a broad spectrum antibiotic effective against most external infections of both marine and freshwater fish. Used as directed, NeoPlex™ will not discolor the water or damage the filter bed. It is well tolerated by invertebrates, although delicate species may be stressed. Active ingredients: neomycin sulfate (43%) Inactive ingredients: excipients (57%) Dosing in WaterRemove all invertebrates - these are extremely sensitive to medication. Turn off UV filters, ozone filters, and remove chemical filtration like MatrixCarbon™ and Purigen®. Use 1 measure (included) per every 8 L (2 US gallons). Repeat this dose every 7 days to a maximum of 3 weeks. This will treat external bacterial infections. Dosing in FoodFeed the medicated food mix every day until the infection clears or up to 1 week. This will treat internal bacterial infections. This medicated food can be refrigerated or frozen between feedings. 1 scoop NeoPlex™1 scoop Focus™1 tbsp food (preferably pellets or frozen food)A few drops of water if using a dry foodTo enhance palatability use with GarlicGuard™ or Entice™. After TreatingWhen the treatment period is over, NeoPlex™ can easily be removed using activated filter carbon like MatrixCarbon™. It does not linger in the substrate or filter media of the tank. Remove with carbon before turning on UV.