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This supplement helps by improving mental clarity and focus, boosting intelligence levels, memory function, and increasing your level of concentration and alertness. As an added bo nus, Neuro Plus can provide you with an increased level of energy and improved mood.* Formula Purposes & Benefits Zero In is formulated to boost cognitive function, mental clarity, focus, immune function, and energy production.Our product is synthesized utilizing the latest scientific research and formulated with high-quality ingredients.Our formula is third-party independently tested for heavy metals, impurities, made in the USA, GMP certified, and produced in an FDA registered facility. 1% of the supplements on the market can match our world-class standards. Formula Ingredient Deck Benefits Of Each Ingredient Vitamin A Supports vision health, skin health, immune health, and increases antioxidant support (182, 183).Supports antioxidant function via decreased inflammatory cytokines (inflammation), decreased reactive oxygen species, and increased l-glutathione production (master antioxidant) (182,183). Supports visual health via increased amounts of plasma vitamin A in macular (eye) tissues (182,183). Vitamin C Supports immune, cardiovascular, skin, cognitive, fat burning, and digestive health (97, 98). Supports immune health via increased oxidant, free radical scavenging, and fueling neutrophilic (immune cell) activity in chemotaxis, phagocytosis, and microbial killing (97,98). Supports fat burning by increasing carnitine biosynthesis (molecule required for mitochondrial fatty acid oxidation) (97,98). Supports accelerate bone healing after a fracture, increase type I collagen synthesis, and reduce oxidative stress (inflammation) (98). Vitamin D Supports exercise performance, immune health, muscle growth, optimal bone health, hormonal health, immune function, increased sexual health, cardiovascular health, glucose tolerance, strength, and positive mood (77,78,79). Supports hormonal health via high amounts of vitamin D receptor (VDR) activity in hormone-based negative feedback loop reactions (77,78). Supports cardiovascular health via improved absorption of calcium, reduced atherosclerotic activity, stimulating cardiomyocytes, and improved vascular health (77,78). Supports exercise performance via reduced exercise-associated inflammation and muscle damage (77,78). Supports sexual health via increased activity of Vitamin D receptor activity of testosterone production (79). Supports immune function via decreases of inflammatory cytokines and aiding immune cells (77,78). Supports joint health via regulating calcium and phosphorus and bone remodeling along with other calcium-regulating actions (77,78). Vitamin E Supports immune function, cognitive health, cardiovascular health, and bone health (204,205,206,207,208) Supports immune health via neutralizing free radicals and reactive oxygen species, and increased T lymphocyte-mediated immune function (204). Supports cardiovascular health via reduced cholesterol (204). Supports cognitive function via reduced oxidative stress, inflammation, and DNA damage of neuronal tissues (208). Vitamin B1 (Thiamine) Supports aerobic energy metabolism (oxidative phosphorylation), cell growth, optimal neuronal conduction (nerve impulses), and cardiovascular health (94). Supports cardiovascular function and aids as a neuroprotective agent in individuals with vitamin B-1 deficiencies (94, 95). Vitamin B2 (Riboflavin) Supports conversion and activation of other B vitamins, red blood cell production and serves as a cofactor for both glucose and fat metabolism (energy production) (92,93). Vitamin B3 (Niacin) Major B vitamin that supports cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9). Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9). Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9). Supports healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9). Prevents pathologies(diseases) such as Pellagra and reduces prevalence of nervous anorexia, cancer, and crohn's disease (10, 11). Supports sensitization of tumors to radiation via apoptosis (cell death) cascade of tumor mass and improves oxygen delivery to malignant tissues (cancer cells) (12). Supports cognitive health by reducing age-related decline of NAD+, increasing quinolinic acid and reducing neuroinflammation (9). Increased niacin associated NAD+ levels have been shown to increase neurotransmission, learning and memory (9). Niacin reduces the prevalence of neurodegenerative pathologies by preventing mitochondrial dysfunction (9). Vitamin B6 Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40). Reduces plasma glucose (blood sugar levels) via by inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39). Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40). May support blood sugar regulation in women with gestational diabetes (40). Cofactor for enzymes involved in DNA metabolism (40). Folic Acid May support proper cell growth and DNA synthesis (65). Biotin Supports conversion of food into cellular energy, hair health, skin health, and cognitive function (213,214). Enhances glucose breakdown into skeletal muscle tissue (213,214). Vitamin B5 Supports energy production, cell growth, cell repair, cognitive function, increased hippocampal volume (memory), and optimized bioenergetics (burning of carbohydrates, fat, and protein) (96). Calcium Supports bone health, muscle function, and cardiovascular health (36,37). Regulates processes of bone resorption, mineralization, and fracture repair (36,37). Increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty (36,37). Prevents the development of preeclampsia (36,37). Iron Supports red blood cell formation, immune function, and antioxidant support (215,216). May increases oxygen uptake into red blood cells of Iron deficient individuals (215,216). May support gut health of iron-deficient individuals. Combats anemia in Iron deficient individuals (217). Magnesium Supports optimal nerve function, muscle contractions, cardiovascular, bone health, and decreased anxiety (90,91). Supports biological reactions such as ATP-fueled reactions and pancreatic insulin secretion (90,91). Supports reduction systolic blood pressure, fasting glucose, triglycerides, and healthy HDL levels (90,91). Reduces peripheral cortisol levels in the CNS and supports relaxation and decreased anxiety (90,91). Zinc Supports immune function, skin health, cognitive function, and vision (172,173). Supports stimulation of the innate and adaptive immune system (172,173). Supports the activation of lymphocytes and activation of innate and T cell-mediated immunity (172,173). Supports cognitive function by modulation of neuronal signaling in areas of the brain associated with memory and learning (hippocampus) (172,173). Selenium Supports antioxidant function, cardiovascular health, cognitive function, thyroid health, and immune health (145, 146). Combats atherosclerosis, high cholesterol (hypercholesterolemia), and type 1 diabetes (147). Supports thyroid health via decreased circulating thyroid autoantibodies in patients with chronic autoimmune thyroiditis (AIT) (146). Increases the activity of selenoproteins that decrease reactive oxygen species (inflammation), increase natural killer activity, and increases glutathione (master antioxidant) levels (145,147). Copper Supports healthy blood sugar levels, energy metabolism and cholesterol management (143,144). Manganese Supports enzymatic antioxidant reactions, increased bone mineral density, and blood sugar regulation (148,149). Chromium Supports insulin function, reduced cholesterol, improved blood sugar regulation, and may lower cholesterol (218,219). Molybdenum Increases enzymatic reactions involved in sulfite metabolism and detoxification (150). DMAE Bitartrate Increases acetylcholine levels in the brain. L-Glutamine The most abundant amino acid in skeletal muscle that fuels immune cells, improves exercise recovery, and optimizes gut microbiome (18). Vital for lymphocyte (immune cell) proliferation (growth) and paramount in neutrophil (immune cell) destruction of bacteria (18). Vital for activation of genetic signals that support immune function and vitality (18). Glutamine is utilized by immune cells at high rates during catabolic conditions (post-surgery, sepsis, burns, and extreme exercise (18). Glutamic Acid Supports cognitive function and focus (220). Green Tea Extract A potent polyphenolic antioxidant that supports blood pressure, insulin sensitivity, and metabolic health (26). High in ECGC (epigallocatechin gallate) (26). ECGC is shown to reduce body fat mass, increase fat oxidation(burning) and increase caloric expenditure during exercise (25). Potent anti-inflammatory compound supporting glutathione production and inhibition of pro-inflammatory markers (cytokines) (26). Reduces oxidative stress (chronic inflammation in the body) (26). Choline Essential for cell membrane integrity, cell messaging, fat metabolism, DNA synthesis, immune support, and nervous system function (62,63). Serves as a methyl donor and as a precursor for the production of cell membranes (62). Precursor for acetylcholine (neurotransmitter) which activates receptors in the central nervous system-mediated immune responses (α7nAchR) (64). Lifelong choline supplementation may combat neurodegenerative diseases by reducing amyloid-β plaque load (plaques of degrading neurons) (62). Reduces the concentration of total homocysteine (inflammation marker) in individuals with low levels of folate and other B vitamins (B₂, B₆, and B₁₂) (62). Inositol Supports liver detoxification, combats metabolic syndrome, and aids as an antioxidant (221). Combats metabolic syndrome via reduced levels of triglycerides, total- and LDL-cholesterol (221). Supports antioxidant function via reduced levels of reactive oxygen species and inflammatory markers (interleukin 6) (222). N-Acetyl Tyrosine Supports memory, cognitive flexibility, the executive function of the brain, and convergent thinking (60). The precursor to dopamine and is vital for dopamine synthesis in the brain (60). Supports cognitive function in individuals with high amounts of stress and anxiety (60,61). Increases dopamine levels in highly stressed individuals (60). Bilberry Fruit Supports vision health, cardiovascular function, increased nitric oxide production, and antioxidant support (223,224). Grape Seed Extract Supports increased nitric oxide production, reduces blood pressure, reduces DNA damage, increases collagen production, increases bone strength, and aids as a neuroprotective agent (31). Supports antioxidant function via modulation of antioxidant enzyme expression, protection against oxidative damage, and reduced reactive oxygen species (31). Supports cardiovascular health via reduced atherosclerosis, inhibiting lipid peroxidation, and improved endothelial vascular function (31). Olive Leaf Supports cardiovascular health, antioxidant function, and controlled blood sugar levels (224). Supports Cardiovascular health via reduction of systolic BP, LDL, and inflammatory biomarkers (224). Supports antioxidant function via anti-inflammatory polyphenols that protect against DNA damage initiated by free radicals (225). Combats major inflammatory pathways via anti-inflammatory change involving inflammation pathway (NF-κB inhibition) (225). Supports blood sugar regulation via improved insulin sensitivity and pancreatic β-cell (cells responsible for secreting insulin) secretory capacity (226). Licorice Root Supports anti-inflammatory, anti-allergenic, and antimicrobial properties (177). Boron Supports increased bone mineral density, muscle function, hormonal balance, and immune function (180). DHA (Fish Oil) Vital for optimal cardiovascular, hormonal, immune, cognitive, digestive health, and recovery from exercise (73,74,76). Fish oil consumption of 6 grams per day has been shown to reduce inflammation, reduce muscle soreness, and reduced the perception of pain in exercising individuals (76). Increases skeletal muscle hypertrophy than individuals consuming only whey protein post-exercise (76). Supports cardiovascular health by decreasing atrial fibrillation, atherosclerosis (plaque buildup), thrombosis, blood pressure, and supporting blood lipid profiles (cholesterol panel) (73,74,75). Lowers blood pressure via increased production nitric oxide production and induced endothelial relaxation (75). Supports healthy information by decreasing c-reactive protein (inflammatory markers) in the body and increasing insulin sensitivity (75,76). Supports cognitive health by increasing the concentration of omega 3 fatty acids in the cell membranes of the cerebral cortex and synaptic vesicles (76). Vanadyl Sulfate Supports blood sugar regulation via improved insulin sensitivity and pancreatic beta-cell function (cells that produce insulin) (227). Phosphatidylserine Supports cognitive function, memory, and focus, and reduced stress (228,229). Reduces prevalence of short-term memory loss in ADHD patients improved prefrontal cortex (PFC) pyramidal cells function (228). Increases dopamine and acetylcholine release via maintenance of acetylcholine supply (228). Reduces cortisol levels in the frontal Brian regions during stressful activity (228,229). Huperzine A Supports cognitive function, memory, focus, and combats neurodegenerative disease (230). Combats neurodegenerative disease via improvement of cognitive function, daily living activity, and global clinical assessment in participants with Alzheimer’s disease (230). Proper Use of This Supplement Suggested Use: As a dietary supplement take two (2) veggie capsules once a day. For best results take 20-30 minutes before a meal with an 8 oz glass of water, or as directed by your health care professional. Our Formula Vs Other Formulas on the Market. 1. Uses third-party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA registered facility. 1. Source cheap ingredients from heavily polluted soils. Even “organic” supplements not third-party tested have been removed by FDA due to high levels of heavy metals. 2. Uses high-quality nutraceuticals in an effective evidence-based and efficaciously dosed formula. 2. Uses cheap sources of nutraceuticals that contain high amounts of fillers, heavy metals, and is formulated without evidence-based dosages. Sources Ueland, P. M., McCann, A., Midttun, Ø., & Ulvik, A. (2017). Inflammation, vitamin B6 and related pathways. Molecular aspects of medicine, 53, 10–27. https://doi.org/10.1016/j.mam.2016.08.001 Bird R. P. (2018). The Emerging Role of Vitamin B6 in Inflammation and Carcinogenesis. Advances in food and nutrition research, 83, 151–194. https://doi.org/10.1016/bs.afnr.2017.11.004 Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., 3rd, Mills, J. L., Pfeiffer, C. M., Fazili, Z., Zhang, M., Ueland, P. M., Molloy, A. M., Caudill, M. A., Shane, B., Berry, R. J., Bailey, R. L., Hausman, D. B., Raghavan, R., & Raiten, D. J. (2015). Biomarkers of Nutrition for Development-Folate Review. The Journal of nutrition, 145(7), 1636S–1680S. https://doi.org/10.3945/jn.114.206599 Thakur, K., Tomar, S. K., Singh, A. K., Mandal, S., & Arora, S. 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A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Archives of ophthalmology (Chicago, Ill. : 1960), 119(10), 1417–1436. https://doi.org/10.1001/archopht.119.10.1417 Jovic, T. H., Ali, S. R., Ibrahim, N., Jessop, Z. M., Tarassoli, S. P., Dobbs, T. D., Holford, P., Thornton, C. A., & Whitaker, I. S. (2020). Could Vitamins Help in the Fight Against COVID-19?. Nutrients, 12(9), 2550. https://doi.org/10.3390/nu12092550 Traber, M. G., & Atkinson, J. (2007). Vitamin E, antioxidant and nothing more. Free radical biology & medicine, 43(1), 4–15. https://doi.org/10.1016/j.freeradbiomed.2007.03.024 Wu, D., & Meydani, S. N. (2014). Age-associated changes in immune function: impact of vitamin E intervention and the underlying mechanisms. Endocrine, metabolic & immune disorders drug targets, 14(4), 283–289. https://doi.org/10.2174/1871530314666140922143950 De la Fuente, M., Hernanz, A., Guayerbas, N., Victor, V. M., & Arnalich, F. (2008). Vitamin E ingestion improves several immune functions in elderly men and women. Free radical research, 42(3), 272–280. https://doi.org/10.1080/10715760801898838 Browne, D., McGuinness, B., Woodside, J. V., & McKay, G. J. (2019). Vitamin E and Alzheimer's disease: what do we know so far?. Clinical interventions in aging, 14, 1303–1317. https://doi.org/10.2147/CIA.S186760 Mock DM. Biotin: From Nutrition to Therapeutics. J Nutr. 2017 Aug;147(8):1487-1492. doi: 10.3945/jn.116.238956. Epub 2017 Jul 12. PMID: 28701385; PMCID: PMC5525106. Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017 Aug;3(3):166-169. doi: 10.1159/000462981. Epub 2017 Apr 27. PMID: 28879195; PMCID: PMC5582478. Cappellini, M. D., Musallam, K. M., & Taher, A. T. (2020). Iron deficiency anaemia revisited. Journal of internal medicine, 287(2), 153–170. https://doi.org/10.1111/joim.13004 Paganini, D., & Zimmermann, M. B. (2017). The effects of iron fortification and supplementation on the gut microbiome and diarrhea in infants and children: a review. The American journal of clinical nutrition, 106(Suppl 6), 1688S–1693S. https://doi.org/10.3945/ajcn.117.156067 Andrews, S. C., Robinson, A. K., & Rodríguez-Quiñones, F. (2003). Bacterial iron homeostasis. FEMS microbiology reviews, 27(2-3), 215–237. https://doi.org/10.1016/S0168-6445(03)00055-X Serving Size: 2 Capsules;Capsules Per Container: 60;Bottle Color: White;Bottle Size: 175cc;Lid Color: White * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Show more