NFH I3C SAP Indole-3-carbinol (I3C) is a phytochemical derived in high concentrations from the Brassica family of vegetables, including broccoli, cauliflower, Brussels sprouts, and cabbage. I3C and its derivative compounds have been shown to exert immunomodulatory effects in the human body. I3C has been shown to exhibit direct antiestrogenic activity via competitive inhibition of estrogen receptors, upregulate the cytochrome P450 isoenzymes CYP1A1, CYP1A2, and CYP1B1, thereby increasing estrogen metabolism, and shift estrogen metabolism away from the more proliferative (16‑OHE1) towards the more protective (2‑OHE1) estrogen species. Size 60 Capsules Benefits Shown to exhibit direct antiestrogenic activity Usage Instructions Take 2 capsule once daily with food. Ingredients Each non-GMO vegetable capsule contains: Indole-3-carbinol 150 mg Non-medicinal Ingredients: Vegetable magnesium stearate and microcrystalline cellulose in a capsule composed of vegetable carbohydrate gum and purified water. NPN : 80072213