SAMe (S-adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health. SAMe is critical for the synthesis of neurotransmitters, is important for energy production in the brain, contributes to the maintenance of healthy cell membrane function, and influences cartilage metabolism.In dogs and cats, SAMe can be helpful for: liver health joint health and mobility age-related behavior changes healthy aging and cognitive function Supplement Facts Active Ingredients:SAMe (S-Adenosyl-L-Methionine)(from S-Adenosyl-L-Methionine Disulfate Tosylate)200 mgOther Ingredients:Hypromellose (cellulose capsule), Microcrystalline Cellulose, Silicon Dioxide and Stearic Acid (vegetable source). Natural color variation may occur in this product.Contents: 60 Veg Capsules Administration Under 20 pounds: 100mg (1/2 capsule) daily 21-40 pounds: 200 mg (1 capsule) daily 41+ pounds: 400mg (2 capsules) daily Should be given one hour before or 2 hours after a meal - ideally should be given on an empty stomach. If GI upset occurs when given on an empty stomach, it can be given with a small amount of food. For pets under 12lbs, the capsule can be opened, half the contents mixed with a small amount of water and syringed into mouth. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.