Marine Bactonical is a unique blend of botanical extracts formulated to help support fish during or after active bacterial infections. It is copper-free, invertebrate safe and can be used simultaneously with other medications.For best results, apply a 10 day course after using NT Labs Marine Anti-Bacterial.Dosage: 100ml bottle treats 400 litres (88 gallons) for 10 days.Directions: Check water quality before use. Remove adsorbent filtration media (activated carbon, phosphate remover) from filters for the treatment period. Turn off UV filtration and/or ozone generators if present. Turn off protein skimmer for a minimum of two hours after each application. Maintain good aeration throughout. Shake bottle thoroughly before use. Use provided pipette to measure required dose and slowly add dose to aquarium. Warning:Monitor skimmer when turning back on - over-skimming may occur.