TO RESOLVE: BACTERIA INFECTIONS PARASITIC INFECTIONS LYME DISEASE General Description Enula is a proprietary blend of the extracts of two plants: Elecampane (Inula helenium), and Jalapa (Ipomoea Jalapa). Elecampane contains inulin which helps promote beneficial intestinal bacteria. This is very important since 70% of the immune system is located in the digestive system. Studies have also shown two other active ingredients in elecampane, alantolactone, and isoalantolactone, to be useful in treating parasites, including roundworm, hookworm, whipworm, and threadworm; this research supports the traditional use of elecampane to treat digestive disorders and parasitic infections. Many practitioners have noted that Enula is effective against certain species of Babesia, a parasite commonly associated with Borreliosis (Lyme disease). Some Reported Medicinal Properties ANTI-PARASITIC ANTI-BACTERIAL LYME DISEASE DIGESTIVE SYSTEM HEALTH Research On NutraMedix Product IN VITRO – LYME DISEASE Priyanka A.S. Theophilus M.S., Eva Sapi Ph.D. (2013). In Vitro Effect of Peruvian Antimicrobial Agents on Borrelia burgdorferi Full Article IN VIVO – ACUTE ORAL TOXICITY TESTS An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Banderol did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article Medical Conditions [peer-reviewed journals] ATOPIC DERMATITIS Wang, Q., Gao, S., Wu, G. Z., Yang, N., Zu, X. P., Li, W. C., ... & Zhang, W. D. (2018). Total sesquiterpene lactones isolated from Inula helenium L. attenuates 2, 4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice. Phytomedicine. Full Article CANCER Zhang, B., Zeng, J., Yan, Y., Yang, B., Huang, M., Wang, L., ... & Lin, N. (2018). Ethyl acetate extract from Inula helenium L. inhibits the proliferation of pancreatic cancer cells by regulating the STAT3/AKT pathway. Molecular medicine reports, 17(4), 5440-5448. Full Article Koc, K., Ozdemir, O., Ozdemir, A., Dogru, U., & Turkez, H. (2018). Antioxidant and anticancer activities of extract of Inula helenium (L.) in human U-87 MG glioblastoma cell line. Journal of cancer research and therapeutics, 14(3), 658. Full Article MALARIA Christy, A. O., Mojisola, C. O. C., Taiwo, E. O., & Ola, O. O. (2016). The antimalaria effect of Momordica charantia L. and Mirabilis jalapa leaf extracts using animal model. Journal of Medicinal Plants Research, 10(24), 344-350. Full Article PANCREATIC CANCER Zhang, B., Zeng, J., Yan, Y., Yang, B., Huang, M., Wang, L., ... & Lin, N. (2018). Ethyl acetate extract from Inula helenium L. inhibits the proliferation of pancreatic cancer cells by regulating the STAT3/AKT pathway. Molecular medicine reports, 17(4), 5440-5448. Full Article PSYCHOPHYSIOLOGICAL DISORDERS Sowndhararajan, K., Cho, H., Yu, B., Song, J., & Kim, S. (2016). Effect of inhalation of essential oil from Inula helenium L. root on electroencephalographic (EEG) activity of the human brain. European Journal of Integrative Medicine, 8(4), 453-457. Full Article RHEUMATOID ARTHRITIS Gao, S., Wang, Q., Tian, X. H., Li, H. L., Shen, Y. H., Xu, X. K., ... & Zhang, W. D. (2017). Total sesquiterpene lactones prepared from Inula helenium L. has potentials in prevention and therapy of rheumatoid arthritis. Journal of ethnopharmacology, 196, 39-46. Full Article VARIOUS CONDITIONS Zia-Ul-Haq, M., Riaz, M., & Feo, V. D. (2012). Ipomea hederacea Jacq.: a medicinal herb with promising health benefits. Molecules, 17(11), 13132-13145. Full Article Medicinal Properties [peer-reviewed journals] ANTI-TUMOR Li, Y., Ni, Z. Y., Zhu, M. C.,Dong, M., Wang, S. M., Shi, Q. W., ... & Cong, B. (2012). Dorn, D. C., Alexenizer, M.,Hengstler, J. G., & Dorn, A. (2006).Phytotherapy Research:An International Journal Devoted to Pharmacological and ToxicologicalEvaluation of Natural Product Derivatives, 20(11), 970-980. ADJUNCT TO CHEMOTHERAPY Seo, J. Y., Park, J., Kim, H. J., Lee,I. A., Lim, J. S., Lim, S. S., ... & Kim, J. S. (2009).,12(5), 1038-1045. ANTI-INFLAMMATORY Park, E. J., Kim, Y. M., Park, S. W.,Kim, H. J., Lee, J. H., Lee, D. U., & Chang, K. C. (2013). ANTISTRESSOR Zelenskaya, K. L., Povet’eva, T.N., Pashinskii, V. G., Fomina, T. N., Timina, E. A., & Perova, A. V.(2005).. ANTIOXIDANT Kumar,S., & Fathima, E. (2017).. Journal of Pharmacognosy and Phytochemistry, 6(6),1502-1508. Tropical Journal of PharmaceuticalResearch, 15(3), 521-526. Albayrak, S., Korkmaz Cinar, A. E.,Paksoy, M. Y., & Aksoy, A. (2015).Iranian Journal of Science and Technology (Sciences),39(4), 473-483. Wang, J., Zhao, Y. M., Zhang, B., &Guo, C. Y. (2015).Indian journal of pharmaceuticalsciences, 77(2), 163. Petkova, N., Vrancheva, R., Mihaylova,D., Ivanov, I., Pavlov, A., & Denev, P. (2015).Journal of BioScience & Biotechnology,4(1). Spiridon, I., Nechita, C., Niculaua,M., Silion, M., Armatu, A., Teacă, C. A., & Bodîrlău, R. (2013). Nesterova, I., Zelenskaia, K. L.,Vetoshkina, T. V., Aksinenko, S. G., Gorbacheva, A. V., & Gorbatykh, N. A.(2003). ANTIBACTERIAL Khan, I., Khan, U.,Khan, W., Subhan, M., Nawaz, M. A., Pervez, S., ... & Ahmad, S. (2017). Stojanović-Radić,Z., Čomić, L., Radulović, N., Blagojević, P., Denić, M., Miltojević, A., ...& Mihajilov-Krstev, T. (2012). O’shea, S., Lucey,B., & Cotter, L. (2009).(4),186-189. ANTINEOPLASTIC Dorn,D. C., Alexenizer, M., Hengstler, J. G., & Dorn, A. (2006).,20(11), 970-980. ANTIPROLIFERATIVE Konishi,T., Shimada, Y., Nagao, T., Okabe, H., & Konoshima, T. (2002).,25(10), 1370-1372. ANTIMICROBIAL Akthar,J. (2016). DIGUȚĂ,C., Cornea, C. P., IONIȚĂ, L., BRÎNDUȘE, E., FARCAȘ, N., Bobit, D., &Matei, F. (2014).. RomanianBiotechnological Letters, 19(5), 9699. Seo,J. Y., Lim, S. S., Kim, J. R., Lim, J. S., Ha, Y. R., Lee, I. A., ... &Kim, J. S. (2008).. Deriu,A., Zanetti, S., Sechi, L. A., Marongiu, B., Piras, A., Porcedda, S., &Tuveri, E. (2008). IMMUNOMODULATING Grigore, A., Neagu, G., Dobre, N., Ionita, C., Ionita, L., & Bobit, D. (2016). Immunomodulatory potential of Inula Helenium L. Analele Stiintifice ale Universitatii" Al. I. Cuza" din Iasi, 62(2), 29. Full Article WOUNDHEALING Butko, А. Y. (2013). Experimental studies of the wound-healing action of Inula helenium and Inula britannica thick extracts on the conventional injury model (phantom) in rats. Клінічна фармація, (17,№ 4), 34-37. Full Article Conference Presentations Cowden Support Program for Lyme: Observational Study – Dublin, Ireland – June, 2012 Armin Schwarzbach, MD PhD Full Video Patient Reports "Has helped tremendously with my Lyme Disease." -D.M. "This is the best defense for my bouts with Lyme Disease. I know the medical industry doesn't want to hear about natural products, but they don't have anything that is as effective!"-A. M. “Had a terrible virus for weeks and Enula Microbial Defense by NutraMedix helped boost my immune system and my energy level has returned to normal.” – G.L “Enula drops are now part of my son's regimen along with traditional antibiotics. He has not gotten sick, even though a virus and the flu are rampant here. I am pleased with Enula Microbial Defense.” – B.B "Doctor prescribed this to help fight a tick-borne infection in addition to antibiotics. So far so good." -T.N. Dosage Information 30 drops twice daily in 4 oz. of water daily (start with 1 drop in 4 oz. of water adding a drop with each dose as tolerated). Safety Information An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Banderol did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article
