Nutramedix, MORA- MICROBIAL DEFENSE
TO RESOLVE: LYME DISEASE INFLAMMATION BACTERIAL INFECTIONS FUNGAL INFECTIONS PARASITIC INFECTIONS General Description Mora is a proprietary blend of the extracts of three plants Bl ackberry, Capirona, and Yarrow. Traditionally, Yarrow (Achillea millefolium) has been used to treat a number of medical conditions. It was used to help stop minor bleeding and to treat wounds, to treat inflammation in a number of conditions, fight fevers, treat gastrointestinal conditions, lessen heavy menstrual bleeding, and improve circulation. Some of the compounds found in Yarrow that may explain its medicinal benefits are apigenin, luteolin, centaureidin, casticin, artemetin, paulitin, isopaulitin, psilostachyin, desacetylmatricarin and sintenin. Traditionally, blackberry leaf tea (Rubus fruticosus) has been used to treat parasites and Capirona (Calycophyllum spruceanum) to treat diabetes, soothe the skin and for fungal, bacterial and parasitic infections. Some Reported Medicinal Properties ANTI-PARASITIC ANTI-BACTERIAL ANTI-FUNGAL ANTI-MOTILITY EFFECT ANTI-OXIDANT ACTIVITY ANTI-NOCICEPTIVE EFFECT (increases tolerance for pain) ESTROGENIC ACTIVITY CHOLERETIC EFFECT CYTOPROTECTIVE Research On NutraMedix Product IN VITRO – LYME DISEASE Priyanka A.S. Theophilus M.S., Eva Sapi Ph.D. (2013). In Vitro Effect of Peruvian Antimicrobial Agents on Borrelia burgdorferi Full Article IN VIVO – ACUTE ORAL TOXICITY TESTS An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Mora did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article Medical Conditions [peer-reviewed journals] ADJUNCTIVE TO CHEMOTHERAPY Miranzadeh,S., Adib-Hajbaghery, M., Soleymanpoor, L., & Ehsani, M. (2015). Effect of adding the herb Achilleamillefolium on mouthwash on chemotherapy induced oral mucositis in cancer patients: A double-blind randomized controlled trial. European Journal of Oncology Nursing, 19(3), 207-213. Full Article ANXIETY Fernández-Demeneghi, R., Rodríguez-Landa, J. F., Guzmán-Gerónimo,R. I., Acosta-Mesa, H. G., Meza-Alvarado, E., Vargas-Moreno, I., &Herrera-Meza, S. (2019). Effect of blackberry juice (Rubus fruticosus L.) on anxiety-like behaviour in Wistar rats. International journal of food sciences and nutrition, 1-12. Full Article CANCER Amini Navaie, B., Kavoosian, S., Fattahi, S., Hajian-Tilaki, K., Asouri, M.,Bishekolaie, R., & Akhavan-Niaki, H. (2015). Antioxidant and cytotoxic effect of aqueous and hydroalcoholic extracts of the Achillea millefolium L. on MCF-7 breast cancer cell line. International Biological and Biomedical Journal, 1(3), 119-125. Full Article ANTIOXIDANT Villalva, M., Jaime, L., Villanueva-Bermejo,D., Lara, B., Fornari, T., Reglero, G., & Santoyo, S. (2019). Supercritical anti-solvent fractionation for improving antioxidant and anti-inflammatory activities of an Achillea millefolium L. extract. Food Research International, 115, 128-134. Full Article Monforte, M. T., Smeriglio, A.,Germanò, M. P., Pergolizzi, S., Circosta, C., & Galati, E. M. (2018). Evaluation of antioxidant, antiinflammatory, and gastroprotective properties of Rubus fruticosus L. fruit juice. Phytotherapy research, 32(7), 1404-1414. Full Article ANTITUMOR Pereira, J. M., Peixoto, V., Teixeira,A., Sousa, D., Barros, L., Ferreira, I. C., & Vasconcelos, M. H.(2018). Achillea millefolium L. hydroethanolic extract inhibits growth of human tumor cell lines by interfering with cell cycle and inducing apoptosis. Food and Chemical Toxicology. Full Article ANTIMUTAGENIC Hussein, A. A., Al-Ezzy, R. M., & Abdallah, M. T. (2019). Biochemical, Enzymatic, and Immunological Study on Antimutagenic Achillea millefolium Methanolic Extract in vivo. Journal of Pharmacy and Pharmacology,7, 69-74. Full Article MULTIPLE SCLEROSIS Ayoobi, F., Moghadam-Ahmadi, A.,Amiri, H., Vakilian, A., Heidari, M., Farahmand, H., ... & Shamsizadeh, A.(2019). Achillea millefolium is beneficial as an add-on therapy in patients with multiple sclerosis: A randomized placebo-controlled clinical trial. Phytomedicine, 52, 89-97. Full Article Medicinal Properties [peer-reviewed journals] ANTI-INFLAMMATORY Benedek, B., Kopp, B., & Melzig, M. F. (2007). Achillea millefolium L. sl–Is the anti-inflammatory activity mediated by protease inhibition?. Journal of Ethnopharmacology, 113(2), 312-317. Full Article Benedek, B., & Kopp, B. (2007). Achillea millefolium L. sl revisited: recent findings confirm the traditional use. Wiener Medizinische Wochenschrift, 157(13-14), 312-314. Full Article ANTIBACTERIAL Thanina, A. C., Mourad, B. E. N. D. A. H. O. U., & Karim, A. R. A. B. (2015). Antibacterial activity of two extracts from Rubus fruticosus L. against resistant pathogens and their antioxidant potential. African Journal of Microbiology Research, 9(18), 1255-1262. Full Article Yakhkeshi, S., Rahimi, S., & Hemati Matin, H. R. (2012). Effects of yarrow (Achillea millefolium L.), antibiotic and probiotic on performance, immune response, serum lipids and microbial population of broilers. Journal of Agricultural Science and Technology, 14(4), 799-810. Full Article Novaković, A. R., Radusin, T. I., Tomšik, A. M., & Ikonić, P.M. (2018). PLA films loaded with Achillea millefolium: In vitro antibacterial effects. Food and Feed Research, 45(1), 45-52. Full Article ANTIMICROBIAL Riaz, M., Ahmad, M., & Rahman, N. (2011). Antimicrobial screening of fruit, leaves, root and stem of Rubus fruticosus. Journal of Medicinal Plants Research, 5(24), 5920-5924. Full Article Shahbazi, Y., & Zadeh, M. S. (2008). In vitro assessment of antimicrobial efficacy of alcoholic extract of Achillea millefolium in comparison with penicillin derivatives. J Anim Vet Adv, 7(4), 508-11. Full Article Candan, F., Unlu, M., Tepe, B., Daferera, D., Polissiou, M., Sökmen, A., & Akpulat, H. A. (2003). Antioxidant and antimicrobial activity of the essential oil and methanol extracts of Achillea millefolium subsp. millefolium Afan.(Asteraceae). Journal of Ethnopharmacology, 87(2-3), 215-220. Full Article ANTIOXIDANT Zafra-Rojas, Q., Cruz-Cansino, N., Delgadillo-Ramírez, A., Alanís-García, E., Añorve-Morga, J., Quintero-Lira, A., ... & Ramírez-Moreno, E. (2018). Organic Acids, Antioxidants, and Dietary Fiber of Mexican Blackberry (Rubus fruticosus) Residues cv. Tupy. Journal of Food Quality, 2018. Full Article Barut, E. N., Barut, B., Engin, S., Yıldırım, S., Yaşar, A., Türkiş, S., ... & Sezen, F. S. (2017). Antioxidant capacity, anti-acetylcholinesterase activity and inhibitory effect on lipid peroxidation in mice brain homogenate of Achillea millefolium. Turkish Journal of Biochemistry, 42(4), 493-502. Full Article Becker, L., Zaiter, A., Petit, J., Zimmer, D., Karam, M. C., Baudelaire, E., ... & Dicko, A. (2016). Improvement of antioxidant activity and polyphenol content of Hypericum perforatum and Achillea millefolium powders using successive grinding and sieving. Industrial Crops and Products, 87, 116-123. Full Article Georgieva, L., Gadjalova, A., Mihaylova, D., & Pavlov, A. (2015). Achillea millefolium L.-phytochemical profile and in vitro antioxidant activity. International Food Research Journal, 22(4), 1347. Full Article Fierascu, I., Ungureanu, C., Avramescu, S. M., Fierascu, R. C., Ortan, A., Soare, L. C., & Paunescu, A. (2015). In vitro antioxidant and antifungal properties of Achillea millefolium L. Rom Biotechnol Lett, 20, 10626-36. Full Article Bhagat, M., & Thusoo, S. (2015). Phytochemical, Cytotoxic and Immunomodulatory Analysis of an Indian Blackberry Rubus fruticosus. Journal of Biologically Active Products from Nature, 5(5), 339-348. Full Article Asnaashari, M., Tajik, R., & Khodaparast, M. H. H. (2015). Antioxidant activity of raspberry (Rubus fruticosus) leaves extract and its effect on oxidative stability of sunflower oil. Journal of food science and technology, 52(8), 5180-5187. Full Article Trumbeckaite, S., Benetis, R., Bumblauskiene, L., Burdulis, D., Janulis, V., Toleikis, A., ... & Jakštas, V. (2011). Achillea millefolium L. sl herb extract: Antioxidant activity and effect on the rat heart mitochondrial functions. Food Chemistry, 127(4), 1540-1548. Full Article Potrich, F. B., Allemand, A., da Silva, L. M., dos Santos, A. C., Baggio, C. H., Freitas, C. S., ... & Marques, M. C. A. (2010). Antiulcerogenic activity of hydroalcoholic extract of Achillea millefolium L.: involvement of the antioxidant system. Journal of Ethnopharmacology, 130(1), 85-92. Full Article Giorgi, A., Mingozzi, M., Madeo, M., Speranza, G., & Cocucci, M. (2009). Effect of nitrogen starvation on the phenolic metabolism and antioxidant properties of yarrow (Achillea collina Becker ex Rchb.). Food Chemistry, 114(1), 204-211. Full Article Teixeira, R. D. O., Camparoto, M. L., Mantovani, M. S., & Vicentini, V. E. P. (2003). Assessment of two medicinal plants, Psidium guajava L. and Achillea millefolium L., in vitro and in vivo assays. Genetics and Molecular Biology, 26(4), 551-555. Full Article Santos, S. S., Rodrigues,L. M., Costa, S. C., & Madrona, G. S. (2017). Antioxidant compounds from blackberry (Rubus fruticosus) pomace: Microencapsulation by spray-dryer and pH stability evaluation. Food Packaging and Shelf Life. Full Article García-Risco, M. R., Mouhid, L., Salas-Pérez, L., López-Padilla,A., Santoyo, S., Jaime, L., ... & Fornari, T. (2017). Biological activities of Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) plant extracts. Plant foods for human nutrition, 72(1), 96-102. Full Article ANTIDIARRHOEL Bais, S., Gill, N. S., & Shandil, S. (2014). Antidiarrhoel activity of methanolic extract of Achillea millefolium L. leaves in albino rats. Der Pharma Chemica, 6(5), 308-14. Full Article ANTIFUNGAL Aydın, S., & Sevindik, E. (2018). Achillea millefolium L. subsp. millefolium essential oil’s antifungal effect. European Journal of Biological Research, 8(3),153-156. Full Article ANTIULCER Cavalcanti, A. M., Baggio, C. H., Freitas, C. S., Rieck, L., De fSousa, R. S., Da Silva-Santos, J. E., ... & Marques, M. C. A. (2006). Safety and antiulcer efficacy studies of Achillea millefolium L. after chronic treatment in Wistar rats. Journal of ethnopharmacology, 107(2), 277-284. Full Article ANTISPASMODIC Moradi, M., Rafieian-Koupaei, M., Imani-Rastabi, R., Nasiri, J., Shahrani, M., Rabiei, Z., & Alibabaei, Z. (2013). Antispasmodic effects of yarrow (Achillea millefolium L.) extract in the isolated ileum of rat. African Journal of Traditional, Complementary and Alternative Medicines, 10(6), 499-503. Full Article ANTITUMOR Tozyo, T., YOSHIMURA, Y., SAKURAI, K., UCHIDA, N., TAKEDA, Y., NAKAI, H., & ISHII, H. (1994). Novel antitumor sesquiterpenoids in Achillea millefolium. Chemical and Pharmaceutical Bulletin, 42(5), 1096-1100. Full Article ANTI-LIMNATIS Bahmani, M., Abdi, F., Adineh, A., Hassanzadazar, H., Eghbali, B., Gholami-Ahangaran, M., & Rafieian-Kopaei, M. (2014). The Anti-Leech Effect of Ethanolic Extract of Achillea Millefolium L. Compared to Levamisole and Niclosamide on Limnatis Nilotica. Studia Universitatis" Vasile Goldis" Arad. Seria Stiintele Vietii (Life Sciences Series), 24(3), 293. Full Article ANXIOLYTIC Baretta, I. P., Felizardo, R. A., Bimbato, V. F., dos Santos, M. G. J., Kassuya, C. A. L., Junior, A. G., ... & Andreatini, R. (2012). Anxiolytic-like effects of acute and chronic treatment with Achillea millefolium L. extract. Journal of Ethnopharmacology, 140(1), 46-54. Full Article HEPATOPROTECTIVE Yaeesh, S., Jamal, Q., Khan, A. U., & Gilani, A. H. (2006). Studies on hepatoprotective, antispasmodic and calcium antagonist activities of the aqueous‐methanol extract of Achillea millefolium. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 20(7), 546-551. Full Article GIT HEALTH Yakhkeshi, S., Rahimi, S., & Hemati Matin, H. R. (2012). Effects of yarrow (Achillea millefolium L.), antibiotic and probiotic on performance, immune response, serum lipids and microbial population of broilers. Journal of Agricultural Science and Technology, 14(4), 799-810. Full Article SPASMOLYTIC Lemmens-Gruber, R., Marchart, E., Rawnduzi, P., Engel, N., Benedek, B., & Kopp, B. (2006). Investigation of the spasmolytic activity of the flavonoid fraction of Achillea millefolium sl on isolated guinea-pig ilea. Arzneimittelforschung, 56(08), 582-588. Full Article WOUND HEALING Nirmala, S., & Karthiyayini, T. (2011). Wound healing activity on the leaves of Achillea millefolium L. by excision, incision, and dead space model on adult wistar albino rats. Int Res J Pharm, 2(3), 240-245. Full Article Hemmati, A. A., Arzi, A., & Amin, M. (2002). Effect of Achillea millefolium extract in wound healing of rabbit. Journal of Natural Remedies, 2(2), 164-167. Full Article VASOPROTECTIVE Dall’Acqua, S., Bolego, C., Cignarella, A., Gaion, R. M., & Innocenti, G. (2011). Vasoprotective activity of standardized Achillea millefolium extract. Phytomedicine, 18(12), 1031-1036. Full Article VARIOUS USES Četojević-Simin, D. D., Ranitović, A. S., Cvetković, D. D., Markov, S. L., Vinčić, M. N., & Đilas, S. M. (2017). Bioactivity of blackberry (Rubus fruticosus L.) pomace: Polyphenol content, radical scavenging, antimicrobial and antitumor activity. Acta Periodica Technologica, 2017(48), 63-76. Full Article Verma, R., Gangrade, T., Punasiya, R., & Ghulaxe, C. (2014). Rubus fruticosus (blackberry) use as an herbal medicine. Pharmacognosy reviews, 8(16), 101. Full Article Zia-Ul-Haq, M., Riaz, M., De Feo, V., Jaafar, H. Z., & Moga, M. (2014). Rubus fruticosus L.: constituents, biological activities and health related uses. Molecules, 19(8), 10998-11029. Full Article Khan, A. U., & Gilani, A. H. (2011). Blood pressure lowering, cardiovascular inhibitory and bronchodilatory actions of Achillea millefolium. Phytotherapy Research, 25(4), 577-583. Full Article Conference Presentations Cowden Support Program for Lyme: Observational Study – Dublin, Ireland – June, 2012 Armin Schwarzbach, MD PhD Full Video Patient Reports "I've used this with success to help calm eczema flare-ups during my metal cleanse; plus, my cat's chin acne. I've also combined it with NutraMedix Houttuynia for nose redness and pain. I think it is great!" -B.LGreat product for Lyme disease like all Cowden products. This is by far the best protocol to address Lyme and the most cost effective too. Strong stuff without side effects. Until now there is no better option available to keep Lyme in remission."-F.S. Dosage Information 30 drops twice daily at least 30 minutes before meals (start with 1 drop in 4 oz. of water adding a drop with each dose as tolerated). Safety Information An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Mora did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article
