NutraMedix Samento is a TOA-free (Tetracyclic Oxindole Alkaloid-free) extract of Uncaria tomentosa (Cat's Claw) — one of the most researched medicinal plants from the Amazon rainforest, used for centuries by Peruvian indigenous communities for immune support, inflammation, and joint health. The TOA-free specification is clinically critical: Cat's Claw contains two chemical types — pentacyclic oxindole alkaloids (POAs), which stimulate the immune system, and tetracyclic oxindole alkaloids (TOAs), which antagonize the immune-stimulating effects of POAs. Samento contains only POAs, maximizing the immune-modulating benefit.POA oxindole alkaloids in Samento stimulate endothelial cell production of lymphocyte-proliferation-regulating factor and activate macrophages and natural killer cells. Research has demonstrated Cat's Claw extract significantly reduces NF-κB (the master inflammatory transcription factor) and IL-6 cytokine levels. A 2024 systematic review and meta-analysis of in vivo studies confirmed its anti-inflammatory and immunomodulatory activities. In vitro studies have shown Uncaria tomentosa extract inhibits SARS-CoV-2 at 98.6% at 25μg/mL concentration. Samento is widely used by integrative practitioners supporting patients with Lyme disease, chronic infections, autoimmune conditions, and chronic inflammation. NutraMedix is a Boca Raton, Florida-based nutraceutical company founded in 1998, sourcing botanical extracts under strict quality and sustainability standards directly from their native habitats in South America. Their herbal liquid extracts use a proprietary extraction process that preserves the full spectrum of active phytochemical constituents in a concentrated, bioavailable liquid form. Available at Beauty Riche — authorized NutraMedix retailer with same-day shipping.
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