Ortho Molecular Ortho B Complex Cardiovascular & Endocrine Health Ortho B Complex is a balanced and comprehensive B complex supplement that contains 5 USP B vitamins, folate, methylcobalamin, and biotin, along with choline and inositol. A wide and complex variety of B vitamins is essential for the body to convert food into cellular energy. This water-soluble group of vitamins is first absorbed in the small intestine and then travels to the liver, where they are biotransformed into their coenzyme forms. One of the key roles of B vitamins is to serve as prime coenzymes for the Krebs’ cycle, the biochemical pathway responsible for maintaining energy production in the form of cellular energy. In addition, B vitamins, particularly folate, B6 , and B12, are required for proper methylation, a biochemical process that helps convert the problematic amino acid metabolite, homocysteine, into the amino acids methionine and cysteine. Proper methylation is critical for supporting many aspects of mental and physical health, including regulating gene expression and DNA repair. Ortho B Complex is a balanced and comprehensive B complex supplement that contains 5 USP B vitamins, folate, methylcobalamin, and biotin, along with choline and inositol. Adequate B vitamin levels are essential for maintaining energy levels, and additional intake is often needed by those with high levels of stress. Ortho B Complex offers high-quality nutrients that help to build a healthy micronutrient reserve, including USP* B vitamins to support energy production and folate for optimal methylation. Key Benefits and Features: Supports Healthy Methylation and Carbohydrate Metabolism Promotes Nervous System, Immune, and Adrenal Health Supports Neurotransmitter Production For A Positive Mood Protects Against Stress-Induced Nutrient Depletion Ingredients Serving Size: 1 Capsule Amount/Serving Thiamin (Vitamin B1) (from Thiamine Hydrochloride USP) 50 mg Riboflavin (Vitamin B2 USP) 50 mg Niacin (as Niacinamide USP) 50 mg Vitamin B6 (as Pyridoxine Hydrochloride USP) 50 mg Folate (800 mcg Folic Acid) 1,360 mcg DFE Vitamin B12 (as Methylcobalamin) 200 mcg Biotin 75 mcg Pantothenic Acid (as d-Calcium Pantothenate USP) 50 mg Choline (as Choline Bitartrate) 19 mg Inositol NF 50 mg Other Ingredients: None. Does Not Contain: Gluten, yeast, corn, artificial colors, or flavors. Suggested Use Take 1 or more capsules per day or as recommended by your health care professional. Warning: If you are pregnant or nursing, consult your physician before taking this product. Keep out of the reach of children. Storage: Keep tightly closed in a cool, dry place. More Info. Deficiency Deficiency in any of the B vitamins can create a breakdown of metabolic processes that protect health. Many medications deplete certain B-vitamins, including acetaminophen, aspirin, ibuprofen, and oral contraceptives. In addition, stress and poor diet also deplete these nutrients. Deficiencies of folate, B6, and B12 can specifically impair proper methylation. Thiamine (Vitamin B1) While naturally abundant in whole grains, thiamine is lost in many of the over-processed grains commonly consumed today. Thiamine is an essential cofactor in the production of ATP in the cells’ Krebs’ cycle and is also needed for the metabolism of fats, proteins, and carbohydrates. A recent randomized double-blind placebo-controlled trial found that supplementation with high-dose thiamine also supports blood sugar balance. Riboflavin (Vitamin B2) Riboflavin is a precursor to flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), both of which are central to energy production and intermediary metabolism, and act as powerful antioxidants. Riboflavin-depleted cells have been found to display signs of oxidative stress and disrupted energy generation. Studies have also shown that optimal riboflavin status has been found to help maintain healthy blood pressure levels in patients with certain genetic predispositions. Niacin (as Niacinamide USP*) Niacin is a cofactor in the mitochondrial respiratory chain, which produces ATP. In the body, niacin is transformed into nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which both play a role in oxidation-reduction reactions in cells. Niacin or nicotinic acid has a long history of use in cardiovascular health, having been shown in numerous studies to support healthy cholesterol levels. Vitamin B6 Vitamin B6 is involved in over 100 enzymatic reactions in the body and is essential for lipid metabolism, neurotransmitter formation, immune health, and hormone modulation. A large, prospective study found that women who consumed, on average, 4.6 mg of vitamin B6 daily had significantly better markers of cardiovascular health compared to women who consumed an average of 1.1 mg daily. In addition, vitamin B6 has been found to boost the immune system in the elderly by increasing the activity of lymphocytes that promote optimal immune function. Folic Acid Often associated with its use in pregnancy to ensure the proper development of healthy neural tubes in babies, folic acid plays a key role in many other functions, including DNA synthesis. Like vitamin B6, folic acid is a key methyl donor14 and helps regulate mitochondrial enzymes and energy metabolism. A study of 1,980 Finnish men over 10 years found that those who consumed the most dietary folate had a significant benefit to their cardiovascular health compared with those who consumed the least amount of dietary folate. Vitamin B12 (Methylcobalamin) Vitamin B12, found only in organ meats, seafood, and egg yolks, often becomes deficient in vegan and vegetarian diets. The vitamin is essential for the metabolism of fats and carbohydrates, the synthesis of proteins, and also plays a role in regulating mitochondrial enzymes and energy metabolism, as well as neurological health. In a population study of 700 women aged 65 and over, more optimal B12 levels were found to be associated with better mood balance and health. Biotin Synthesized by the bacteria in the gut in addition to certain foods, biotin and its cofactors are involved in the metabolism of fatty acids, amino acids, and the utilization of B vitamins. Biotin has also been found to support healthy blood sugar, both in animal and human studies. A randomized, double-blind, placebo-controlled clinical trial conducted among 70 patients aged five to 25 years old, with blood sugar concerns, found biotin administration to promote blood sugar balance as well as healthy blood fats. Pantothenic Acid Pantothenic acid and its biologically active derivative, CoA, are essential to the synthesis of important fatty acids, membrane phospholipids, amino acids, steroid hormones, and energy production. 95% of CoA is found in the mitochondria. Pantothenic acid has also been shown to have a balancing effect on blood fats in animal studies and has also been shown in research to support normal tissue repair and recovery. Choline Bitartrate Though not technically a B vitamin, choline is often associated with B vitamins. It is important in the construction of cell membranes and plasma lipoproteins, plays a role in cell signaling, and in the synthesis of acetylcholine (a neurotransmitter), and is vital for brain development. *The USP is a scientific organization that sets standards for the identity, strength, quality, and purity of medicines, food ingredients and dietary supplements, manufactured, distributed and consumed worldwide.
