Orthoplex SAMe 400mg proudly contains one of the most biologically active and stable forms of S-adenosylmethionine available - the Swiss patentedAdonat®. The Adonat® in Orthoplex SAMe 400mg is naturally derived and solvent free, obtained through the biofermentation of Saccharomyces cerevisiae yeast cultures. Indications: Supports healthy liver and immune system function Helps support emotional and general mental wellbeing Maintains natural liver detoxification processes Adult Dose: Take 1-3 tablets daily, or as recommended by your registered healthcare practitioner. Ingredients: Each tablet contains (S)-S-Adenosylmethionine disulfate tosylate (Adonat®) 800.0mg equiv. (S)-S-Adenosylmethionine 400.0mg Pyridoxal 5-phosphate monohydrate 5.41mg equiv. Pyridoxine 3.45mg Pyridoxine hydrochloride 25.0mg equiv. Pyridoxine 20.6mg Riboflavin 10.0mg Zinc amino acid chelate 25.0mg equiv. Zinc 5.0mg Warnings: Large tablet. Swallow with a glass of water. Stop taking this medication if you experience tingling, burning or numbness and see your healthcare practitioner as soon as possible (contains vitamin B6). Individuals who are using prescription antidepressants or suffer from bipolar depression should not use this product unless under the supervision of a healthcare practitioner. Stability: SAMe has been specifically formulated to tolerate short term temperature increases to allow for transit outside of refrigeration. A significant quantity of increased overage has been included into the formulation to ensure that the dosage of (S)-S-Adenosylmethionine is maintained for up to 7 days transit time at ambient room temperature without refrigeration.