Zonulin1 is a uniquely formulated to regulate tight junctions in the gastrointestinal tract and blood. Zonulin1 reduces serum zonulin, intestinal hyperpermeability, inflammation in the gut and neuroinflammation all of which are associated with many common autoimmune diseases. The components in Zonulin1 ingredients, including saikosaponin, paeoniflorin, naringin and glycyrrhizic acid have powerful sorbefacient effects that regulate tight junctions. Zonulin is an inflammatory protein first discovered by Fasano and his team in 2000. It helps regulate leakiness in the gut by opening and closing the spaces or ‘junctions’ between cells in the lining of the digestive tract (1). Zonulin is normally present in the intestines to control the passage of fluids, macromolecules, and leukocytes, but this protein appears to be overexpressed in patients with autoimmune conditions, resulting in increased intestinal permeability (2). Intestinal hyperpermeability occurs when there’s a breakdown in the function of zonulin, allowing larger particles such as bacteria, toxins, and partially digested food particles through the intestinal walls to the bloodstream, where the immune system generates a reaction to clear them out. In genetically-susceptible individuals, these substances can eventually elicit an exaggerated or erroneous response, and the body can begin to assault its own tissue (3). Zonulin up-regulation seems to precede the onset of the disease, providing a possible link between increased intestinal permeability, environmental exposure to non–self-antigens, and the development of autoimmunity (4). Indications: Leaky Gut Auto-immune diseases including: Atopic dermatitis Inflammatory Bowel Diseases Celiac Disease Chronic Fatigue Syndrome Multiple Sclerosis Rheumatoid Arthritis Actions: Helps repair gastrointestinal tight junctions Lowers serum Zonulin Reduces intestinal hyperpermeability Down-regulates inflammatory cytokines Reduces neuro-inflammation-mediated neuro-degeneration through suppressing NF-κBmediated inflammatory pathways Dose: As prescribed by your healthcare professional. Ingredients: Bupleurum falcatumPaeonia lactiflora Citrus aurantium Glycyrrhizae uralensis Lactobacillus acidophilus Warning: Prescription only. Only to be used under the supervision of your healthcare professional.
