Effective EPM Treatment Paste for Horses Product Description Marquis® (15% ponazuril) is a prescription oral paste formulated to treat Equine Protozoal Myeloencephalitis (EPM) in horses. It targets the underlying protozoal infection while supporting neurological recovery. The easy to administer syringe ensures accurate dosing, including a loading dose for rapid therapeutic levels, making it a reliable and clinically proven solution for managing EPM in horses. Benefits Targets Protozoa: Effectively eliminates Sarcocystis neurona, the primary cause of EPM, addressing the root of neurological disease in horses. Easy Oral Dosing: Comes in a calibrated syringe paste that allows precise weight-based dosing and convenient daily administration. Neurological Support: Aids in coordination and alleviates neurological deficits, and many horses treated show measurable clinical improvement. Proven Effectiveness: Clinically proven to be effective, with up to 60 percent of horses treated showing improvement of at least one neurological grade. Rapid Drug Levels: Loading dose strategy helps achieve steady therapeutic concentrations quickly, supporting faster onset of treatment action. Variants 127 g syringe applicator Ingredients Ponazuril 150 mg per gram How to Use Recommended-Dosage Chart Horse Weight Day 1 (Loading Dose) Day 2–28 (Maintenance Dose) 600–1,200 lbs (272–544 kg) 15 mg/kg 5 mg/kg once daily Dosage & Administration Instructions Initial Loading Dose: Administer three consecutive doses on the first day to achieve the required 15 mg/kg loading dose. Daily Maintenance Dose: Continue with a single daily dose of 5 mg/kg for the remaining 27 days. Weight Adjustment: Use the syringe dosage ring to match the dosage to the horse's body weight, so the dose is correct every time. Proper Administration: Place paste on the back of the tongue and raise the horse’s head briefly to aid swallowing. Prescription Required: This medication is restricted to veterinary use and should only be administered under professional supervision. Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet. Additional Information Precautions Confirm Diagnosis: Make sure the diagnosis of EPM is correct and differentiated from other neurological or musculoskeletal conditions before treatment. Early Symptom Worsening: Neurological signs such as ataxia may transiently worsen during the early days of treatment. Incomplete Recovery: Neurological damage may not be completely reversed by elimination of the parasite, depending on the severity and duration of the disease. Limited Safety Data: The safety has not been established in breeding horses, pregnant mares, lactating mares, or with other therapies. Human Consumption Restriction: Do not administer this product to horses intended for human consumption at any stage of their production. Possible Side Effects Skin Reactions: Some horses may develop rashes, hives, or skin irritation lasting several days during treatment. Digestive Issues: Loose stools or mild digestive disturbances have been observed in some horses during administration. Oral Lesions: Blisters around the mouth or nose have been reported in rare cases during treatment. Neurological Changes: Temporary worsening of neurological signs, such as ataxia, may occur during early treatment stages. Rare Events: Isolated cases of mild colic or seizures have been reported, though direct association is not confirmed. Storage Information Controlled Temperature: Store the product at temperatures between 20 and 25 degrees Celsius for optimal stability. Allowed Excursions: Short-term storage between 15 and 30 degrees Celsius is acceptable without affecting product quality. Secure Storage: Keep the syringe tightly capped and stored safely away from children and unauthorized access. Shipping & Return We offer ground, express, priority, and international delivery; see our shipping policy for details. For return instructions or product concerns, please refer to our detailed refund policy. Prescription items are NON-RETURNABLE and NON-REFUNDABLE. Frequently Asked Questions Q1: What is Marquis used for in horses? Ans: Marquis is used to treat Equine Protozoal Myeloencephalitis, a neurological disease caused by Sarcocystis neurona. It targets and removes the protozoal infection. This helps improve neurological function and coordination in affected horses when given as directed by a veterinarian. Q2: How long does the Marquis treatment take to show results? Ans: Treatment typically lasts 28 days, and clinical improvement may be observed within weeks. In studies, horses were evaluated up to 118 days, with many showing at least one grade improvement in neurological condition, depending on disease severity and duration before treatment began. Q3: How is Marquis paste administered to horses? Ans: Marquis is given by mouth with a calibrated syringe. Place the paste on the back of the horse’s tongue and make sure the mouth is empty of feed. Adjust the dosage based on the horse's body weight. Raise the horse’s head briefly to help with swallowing. Q4: Are there any side effects associated with Marquis? Ans: Some horses may experience side effects such as skin rashes, loose stools, oral blisters, or mild colic. In rare cases, neurological signs may temporarily worsen during early treatment. These effects are not always directly linked to the medication but should be monitored. Q5: Can Marquis be used in all horses? Ans: Marquis is intended for horses only. It should not be used in horses raised for human consumption. Its safety has not been checked in breeding, pregnant, or lactating horses. Therefore, you should seek veterinary advice before using it in these groups.
