Enzyme Science (PEA)+ Ultra-Micronized PEA with Meriva® Curcumin With ultra-micronized PEA (naturally derived from safflower seeds) and Meriva® curcumin phytosome.(PEA)+ relieves stress, soreness, and discomfort associated with occasional pain, stiffness, and compromised tissue function. Naturally affects the bliss molecule that helps promote joy. Ultra-micronized PEA is the clinically proven superior form. Meriva® curcumin phytosome is highly bioavailable. Key Benefits and Features: For stress & overexertion Nervous system support Clinically proven form of PEA Ingredients Serving Size: 2 Vegetarian Capsules Amount/Serving Meriva® 500 mg Curcumin Phytosome Phosphatidylcholine Complex (Curcuma longa)(rhizome)(18-22% curcuminoids) Ultra-Micronized PEA (Palmitoylethanolamide) 300 mg Other Ingredients: 100% Vegetarian Capsule (HPMC, water). Does Not Contain: Casein, crustaceans, eggs, fish, gluten, milk, nuts, sesame, shellfish, soy, wheat, artificial colors, fillers, or flavors. Vegan, Dairy Free, Gluten Free, Soy Free Suggested Use Take 2 capsules twice daily, with or without food. More may be taken as recommended by your healthcare practitioner Warning: Consult with a physician prior to use if you are pregnant or nursing, taking medications, or have a medical condition. Keep out of reach of children. Storage: Keep tightly closed in a cool, dry place. More Info. Palmitoylethanolamide (PEA) is an extensively researched natural ingredient for important neuroprotective actions. This ingredient has been utilized for decades and is available in dietary supplements worldwide as an option for the onset of physiological stress.PEA is an endogenous fatty acid amide that belongs to the family of biologically active lipids that are increased by the body to soothe discomfort naturally. PEA was identified over 60 years ago when it was isolated from extracts of the brain, liver, and muscle of rats and guinea pigs. It was later found to be contained in chicken egg yolk, olive oil, safflower and soy lecithin, peanut meal, and several other foods.Since PEA is a lipid that has a large particle size in its unprocessed state, this can limit its solubility and bioavailability. However, ultra-micronized PEA has been processed using an air-jet milling technique. Both its particle size and purity are then confirmed. Research shows that, in animal studies, this form of PEA has a “superior” action. That’s why we use this form in (PEA)+.The biological properties and mechanisms of PEA naturally produced by the body involve a variety of effects, including those upon glial and mast cells, cannabinoid-2 receptors, NF-kB, and effects on the nuclear receptor peroxisome proliferator-activated receptors. Glial and mast cells naturally play a key role in the body’s management of discomfort. Cannabinoid-2 receptors are more often found on immune cells, in the gastrointestinal tract, and in the peripheral nervous system. In addition, PEA enhances the effects of the fatty acid anandamide (also referred to as the “bliss molecule”) when it binds to CB receptors.
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