Clinical Applications Perfect Digestion is a cost-effective, non-prescription, broad-spectrum, digestive enzyme formula suitablefor vegans and designed to support the digestion of fat, protein, carbohydrate, fiber, and lactose. Thiscomprehensive formula contains lipase, proteases, alpha-galactosidase, hemicellulase, papain, lactase,and other key digestive enzymes. Perfect DigestMax works in a wide pH range—unlike porcine pancreatin,which works in a narrow pH range.* DiscussionDigestion Food must be broken down into its component parts in order to be absorbed into the bloodstream. Thoughsalivary secretions, chewing, gastric acid, and pepsin begin the process of digestion, the majority of digestion takes placefarther down the gastrointestinal tract in the small intestine. Once food leaves the stomach and enters the small intestine,digestive enzymes begin the monumental task of turning it into the building blocks and fuel that the body needs for structuralsupport and metabolic processes. Digestive enzymes are produced primarily in the pancreas and brush border of the smallintestine, and the health and function of these organs is vital to effective digestion and absorption. Proteolytic enzymes,amylases, and lipases are responsible for the digestion of proteins, carbohydrates, and fats. The complete digestion ofthese macronutrients produces small peptides, amino acids, monosaccharides and disaccharides, and free fatty acids thatcan easily pass through the intestinal microvilli and enter the bloodstream. Healthy digestion assures that incompletelydigested molecules and proteins don’t enter the bloodstream where they may be recognized as “foreign” by a vigilantimmune system.*[1,2]Pancreatic and Intestinal Enzymes Pancreatic production of proteases, amylases, and lipases is complemented byintestinal production of lactase, maltase, sucrase, enterokinase, and various peptidases, highlighting the importance of thepancreas and the intestines in the digestive process. The enzyme lactase is required to break down lactose into glucoseand galactose before the intact lactose can draw excess water into the bowel, and before colonic bacteria can break itdown into volatile gases and acids. Though lactose (a disaccharide found only in mammals’ milk) is readily digested bymost infants, normal production decreases as a child is weaned onto whole foods and may eventually cease in adulthood. Exogenous administration of lactase can support lactose digestion effectively and allow for continued consumption of milk-based products. Maintaining a healthy gastrointestinal flora helps support brush border function and digestive capacity as well.Digestion of Plant-Based Compounds Perfect Digestion contains several principle digestive enzymes as well as acomplement of enzymes designed to break down plant compounds and fibers that humans would otherwise be unable todigest. Raffinose and melibiose, carbohydrates commonly found in legumes, can be broken down by the intestinal enzymealpha-galactosidase. In the absence of this enzyme, these carbohydrates pass into the large intestine, where microbes can ferment them and produce volatile gases. Exogenous administration of alpha-galactosidase, present in Digestion, supports the digestion of these plant-based compounds and has been used safely and effectively. Beta-glucanase,hemicellulase, pectinase, xylanase, and dipeptidyl peptidase (DPPIV) are also present and improve the digestibility of plant-based foods by breaking down plant cell walls, fibers, and proteins. Phytase is present to facilitate the breakdown ofindigestible phytates from grains and seeds, and release phosphorus, calcium, inositol, and other nutrients for absorption. Bromelain and papain offer additional support for protein digestion. The enzyme invertase catalyzes sugar to glucose and fructose. Perfect Digestion incorporates amylase, lipase, proteases, hemicellulase, bromelain, papain, lactase, DPPIV, and other key digestive enzymes to provide a comprehensive formulation that functions in a wide pH range to support and facilitate healthy digestion. It has been formulated to allow flexible dosing that can be adjusted for individual needs. DirectionsTake one to two capsules daily, or use as directed by yourhealthcare practitioner. If necessary, capsules may beopened and contents sprinkled over food.Consult your healthcare practitioner prior to use.Individuals taking medication should discuss potentialinteractions with their healthcare practitioner. Do not useif tamper seal is damaged. Does Not Contain Wheat, gluten, yeast, soy, animal or dairy products, fish,shellfish, peanuts, tree nuts, egg, ingredients derivedfrom genetically modified organisms (GMOs), artificialcolors, or artificial sweeteners.Maltodextrin (derived from corn) is used to standardizeenzyme activity.
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