Significant research supports the cardiovascular benefits of L-arginine in promoting vascular health and blood flow. L-arginine enhances nitric oxide production in the arteries, which in turn relaxes blood vessels and maintains healthy blood flow. Perfusia Plus combines sustained-release L-arginine with nutritional cofactors that enhance nitric oxide synthesis in the blood vessels (5-MTHF and ascorbic acid), in addition to antioxidants and botanicals that promote normal blood flow (R-lipoic acid, green tea extract, and resveratrol). L-arginine is a semi-essential amino acid that is involved in multiple areas of human physiology and metabolism. It has a significant effect on endocrine function and helps regulate the release of neurotransmitter chemicals, insulin, glucagon (which has the opposite effect of insulin; i.e., it raises blood sugar), and growth hormone. However, one of L-arginine's most compelling contributions to human physiology is its role as a biological precursor of nitric oxide.