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Personalized Anaesthesia: Targeting Physiological Systems for Optimal Effect
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Cambridge University PressEdition: Illustrated, 2/6/2020EAN 9781107579255, ISBN10: 1107579252Paperback, 400 pages, 24.6 x 18.8 x 1.5 cmLanguage: EnglishPersonalized Anaesthesia pre
sents a modern vision of anaesthesia. Integrating technology and knowledge from leading experts in the field, this book will change the way anaesthesia is both taught and practiced. Modern practice requires the anaesthetist to provide patient-specific management. This is the first resource to be organised by the desired physiological effect, rather than by drug groupings, explaining how physiological changes can be produced and controlled according to the characteristics of each patient and the particular surgical context. The book integrates physiology, pharmacology and technology, and applies these concepts in a systematic manner to each homeostatic system. This will optimise drug titration, effect quantification and decision making in anaesthesia practice to match the needs of the individual patient. Complex mathematical and scientific concepts are explained using accessible text, colour illustrations throughout and graphs. This is an essential text for any consultant or trainee working in anaesthesia.ForewordIntroductionPart I. Basic Principles1. Principles of quantitative clinical pharmacology Pedro L Gambús and Sebastián Jaramillo2. Pharmacokinetic and pharmacodynamic modeling in anaesthesia MarÃÂa J. Garrido and Iñaki F. Trocóniz3. Drug interactionsadditivity and synergy among anaesthetic drugs Jacqueline A. Hannam and Timothy G. Short4. Covariate analysis in clinical anaesthesia Luis I. Cortinez and Brian J. Anderson5. Signal analysis and response measurement Umberto Melia, Erik W. Jensen and José F. Valencia6. Application of PKPD and signal analysis to drug administration in anaesthesia Ross R. KennedyPart II. Targeting Effects7. Hypnotic effectinducing unconsciousness and emergence from anaesthesia Sergio Vide, Catarina Nunes and Pedro Amorim8. Analgesiaeffects on response to nociceptive stimulation Emmanuel Boselli and Mathieu Jeanne9. Personalized sedation and analgesia Michael M. Beck, Jeffrey B. Horn and Ken B. Johnson10. Respiratory depression Malin Jonsson Fagerlund11. Immobility Klaus T. Olkkola and Douglas J. Eleveld12. Effects on brain function Neus Fabregas and Adrian W. Gelb13. Targeted and individualized perioperative medicine for cognitive dysfunction Pauline Glasman, Alice Jacquens and Vincent Degos14. Cardiac and hemodynamic function Kai Kuck, Natalie Silverton and Michael K. Cahalan15. Effects of anaesthesia on thermoregulation Oliver Kimberger16. Effects of perioperative management on kidney function Xavier Borrat and Jordi Mercadal17. Effects on liver function Andre M. De Wolf and Jan F. A. Hendrickx18. Effects on fluid balance Robert G. Hahn19. Ventilation during general anaesthesia LluÃÂs Gallart20. Epilogueartificial intelligence methods Sebastián Jaramillo, José F. Valencia and Pedro L. GambúsIndex.
