SkinCeuticals Phloretin CF 30ml — Advanced Vitamin C Antioxidant Serum for Bright, Even, Protected Skin

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Clinical Summary: SkinCeuticals Phloretin CF is a patent-protected daytime antioxidant serum containing 2% phloretin, 10% L-ascorbic acid, and 0.5% ferulic acid, formulated to deli ver broad-spectrum protection against free radical damage from UV radiation, ozone, and visible light while inhibiting melanin synthesis to address mixed dyschromia and post-inflammatory hyperpigmentation. The synergistic triple-antioxidant combination is supported by peer-reviewed research by Pinnell et al. demonstrating superior free radical neutralisation compared to single-antioxidant formulations. Manufactured by SkinCeuticals (L'Oréal Group) under ISO 22716:2007 GMP standards and available in Singapore through EMIS for dermatology and aesthetic clinic supply. SkinCeuticals Phloretin CF — Product Overview SkinCeuticals Phloretin CF is a daytime antioxidant serum formulated with a patent-protected combination of 2% phloretin, 10% L-ascorbic acid (vitamin C), and 0.5% ferulic acid. Phloretin is a dihydroxychalcone polyphenol originally isolated from apple tree bark, characterised by potent free radical scavenging activity and specific inhibition of glucose transporter GLUT1 in epidermal keratinocytes, which suppresses melanin synthesis and addresses mixed pigmentation. L-ascorbic acid at 10% concentration provides direct antioxidant neutralisation of superoxide, hydroxyl, and peroxyl radicals generated by UV and environmental pollution exposure. Ferulic acid, a hydroxycinnamic acid derivative, enhances the photostability of both L-ascorbic acid and alpha-tocopherol while contributing additional free radical scavenging capacity — a synergistic effect documented by Duke University research and published in the Journal of Investigative Dermatology. The combination has been clinically validated in double-blind, vehicle-controlled studies demonstrating reductions in UV-induced erythema, melanin indices, and surface roughness parameters. The acidic pH (pH 3.0–3.5) of the formulation is required to maintain L-ascorbic acid in its bioavailable, non-ionised form capable of percutaneous penetration to the stratum spinosum. This formulation is particularly indicated for patients with normal-to-oily or combination skin presenting with actinic pigmentation, acne-related post-inflammatory hyperpigmentation, or photodamage requiring a lightweight, non-occlusive antioxidant vehicle suited to Singapore's high-humidity environment. The product is manufactured under L'Oréal's ISO 22716:2007-certified GMP framework and notified as a cosmetic product under the Singapore HSA Health Products Act (Cap. 122D). Product Specifications Parameter Specification Manufacturer SkinCeuticals (L'Oréal Group), France SKU / EAN Barcode 635494328202 Net Volume 30 mL Key Active Ingredients 2% Phloretin (dihydroxychalcone from apple); 10% L-Ascorbic Acid (pure vitamin C); 0.5% Ferulic Acid Formulation pH pH 3.0–3.5 (required for L-ascorbic acid bioavailability and percutaneous penetration) Formulation Type Lightweight aqueous serum; silicone-free; paraben-free; fragrance-free; dye-free Application Timing Morning (daytime antioxidant); apply post-cleanse before SPF moisturiser Suitable Skin Types Normal, oily, combination, acne-prone; Fitzpatrick Types I–VI Manufacturing Standard ISO 22716:2007 Good Manufacturing Practices for Cosmetics Regulatory Status (Singapore) Cosmetic product notified under HSA Health Products Act (Cap. 122D); ASEAN Cosmetic Directive compliant Retail Price (Singapore) SGD 285 per 30 mL Storage Conditions 15–25°C; protect from direct sunlight and heat; do not refrigerate Clinical Indications and Aesthetic Applications Actinic pigmentation and solar lentigines: Phloretin's GLUT1 inhibition in melanocytes suppresses melanin synthesis upstream of tyrosinase, complementing downstream inhibitors. Indicated for Fitzpatrick II–V patients with UV-induced pigment irregularity requiring daytime antioxidant and depigmentation support. Post-inflammatory hyperpigmentation (PIH) in acne-prone skin: Appropriate for oily and combination skin types where heavy emollients are contraindicated; the lightweight serum vehicle delivers depigmenting activity without comedogenic risk in active or post-acne patients. Comprehensive photoprotection in Singapore's high-UV climate: Applied under SPF, Phloretin CF neutralises reactive oxygen species not blocked by chemical UV filters, particularly visible light and infrared-generated free radicals that contribute to pigmentation and collagen degradation in equatorial UV environments (UV Index 11–14). Post-procedure brightening maintenance: Suitable post-laser, post-peel, or post-IPL (once re-epithelialisation is complete) to maintain treatment gains and prevent recurrent pigment formation via antioxidant and melanogenesis inhibition. Combination antioxidant protocols: Used as the daytime component of a 24-hour antioxidant regimen paired with a nighttime antioxidant (e.g., Resveratrol B E) for comprehensive oxidative protection; particularly relevant for patients with high occupational or recreational UV/pollution exposure. Pre-operative skin conditioning: Prescribed by plastic surgeons and aesthetic physicians in the pre-operative period to improve skin quality, reduce inflammation, and support optimal wound healing following planned facial procedures. Frequently Asked Questions Q: What is the role of phloretin specifically, and how does it differ from L-ascorbic acid?A: L-ascorbic acid is the primary direct antioxidant in this formulation, neutralising singlet oxygen, superoxide, and hydroxyl radicals generated by UV exposure. Phloretin contributes additional free radical scavenging capacity and, critically, inhibits glucose transporter GLUT1 in epidermal cells, reducing intracellular glucose availability required for melanin biosynthesis — a mechanism distinct from tyrosinase inhibition used by kojic acid or niacinamide. Ferulic acid stabilises both L-ascorbic acid and phloretin against photo-oxidative degradation, significantly extending the effective antioxidant lifespan of the applied product. Q: Why does the product have an acidic pH and can it cause skin irritation?A: The pH 3.0–3.5 of Phloretin CF is required to maintain L-ascorbic acid in its uncharged, lipid-soluble form capable of penetrating the stratum corneum. At higher pH values (>4.0), ascorbic acid ionises and cannot cross the lipid barrier, rendering it topically ineffective. In patients with intact skin barrier, this pH is well tolerated. Patients with compromised barrier (active eczema, rosacea, or post-procedure erythema) should use with caution or as directed by their dermatologist; a brief stinging sensation on first application is common and typically resolves with continued use as the skin adapts. Q: How does Phloretin CF compare to SkinCeuticals C E Ferulic for Singapore patients?A: Both products are daytime antioxidant serums, but they are optimised for different skin types and indications. C E Ferulic contains 15% L-ascorbic acid and is better suited for dry, normal, or mature skin requiring maximum vitamin C concentration. Phloretin CF at 10% L-ascorbic acid plus 2% phloretin is formulated for oily, combination, and pigmentation-prone skin types, with additional depigmenting activity via GLUT1 inhibition. Clinicians in Singapore frequently prescribe Phloretin CF for patients with mixed pigmentation, acne-prone skin, or those who find C E Ferulic too heavy in high humidity. Q: When should patients apply Phloretin CF in their routine?A: Phloretin CF is a daytime-only product applied after cleansing and toning, before any serums, SPF moisturiser, or sunscreen. Application should precede any moisturiser to allow the acidic antioxidants to penetrate skin before occlusion. A single application of 4–5 drops to the face and neck is sufficient; the product should be massaged gently and allowed to dry for 1–2 minutes before layering SPF. Per Singapore MOH dermatology guidance, SPF 30+ (preferably SPF 50) broad-spectrum sunscreen is mandatory as the final daytime step. Q: Is institutional procurement available through EMIS for Singapore clinics?A: Yes. EMIS Singapore supplies SkinCeuticals Phloretin CF to aesthetic clinics, dermatology practices, and hospital pharmacy units as HSA-notified cosmetic products under the ASEAN Cosmetic Directive and Health Products Act (Cap. 122D). Volume pricing, clinical protocol guidelines, and patient education materials are available for institutional buyers; contact the EMIS procurement team for institutional terms. { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What is SkinCeuticals Phloretin CF 30ml \u2014 Advanced Vitamin C Antioxidant Serum for Bright, Even, Protected Skin used for?", "acceptedAnswer": { "@type": "Answer", "text": "SkinCeuticals Phloretin CF 30ml \u2014 Advanced Vitamin C Antioxidant Serum for Bright, Even, Protected Skin is a topical skincare product available from EMIS+ (emis.asia) in Singapore, applied to the skin as directed on the packaging. Individual results vary, and products should be chosen to suit your skin type and concerns." } }, { "@type": "Question", "name": "How do I use SkinCeuticals Phloretin CF 30ml \u2014 Advanced Vitamin C Antioxidant Serum for Bright, Even, Protected Skin?", "acceptedAnswer": { "@type": "Answer", "text": "Apply as directed on the product packaging. Introduce new products gradually and perform a patch test on a small area first, especially if you have sensitive or reactive skin. If irritation persists, stop use and consult a doctor or dermatologist (for example at the National Skin Centre or a private clinic in Singapore)." } }, { "@type": "Question", "name": "Is SkinCeuticals Phloretin CF 30ml \u2014 Advanced Vitamin C Antioxidant Serum for Bright, Even, Protected Skin available without prescription in Singapore?", "acceptedAnswer": { "@type": "Answer", "text": "Yes. SkinCeuticals Phloretin CF 30ml \u2014 Advanced Vitamin C Antioxidant Serum for Bright, Even, Protected Skin is available from EMIS+ (emis.asia) without a prescription. For persistent or medical skin concerns, consult a dermatologist or your doctor." } }, { "@type": "Question", "name": "Where can I buy SkinCeuticals Phloretin CF 30ml \u2014 Advanced Vitamin C Antioxidant Serum for Bright, Even, Protected Skin in Singapore?", "acceptedAnswer": { "@type": "Answer", "text": "SkinCeuticals Phloretin CF 30ml \u2014 Advanced Vitamin C Antioxidant Serum for Bright, Even, Protected Skin is available from EMIS+ at emis.asia, Singapore's nurse-led medical and wellness supply store, with fast island-wide delivery. Bulk orders for clinics and care facilities are welcome \u2014 contact us at emis.asia/pages/contact." } }, { "@type": "Question", "name": "Do I need to patch test this serum, or check with a doctor first?", "acceptedAnswer": { "@type": "Answer", "text": "Patch test on a small area before first full use, particularly if you have sensitive skin, rosacea or eczema. Active vitamin C serums can cause temporary tingling. If you are pregnant, breastfeeding, using prescription retinoids or undergoing dermatological treatment, check with your doctor, pharmacist or dermatologist before adding a new active serum to your routine. Discontinue use and seek advice if persistent irritation occurs." } } ] } Show more