ProDen PlaqueOff Powder is a 100% natural pet food supplement containing the natural and organic kelp ingredient A.N ProDen - shown in clinical trials to help reduce plaque and tartar and to help improve bad breath. The results are usually seen between 3 to 8 weeks, with continued use. Sprinkle the powder over the dog's ordinary food, wet or dry, once a day with the supplied scoop. ProDen PlaqueOff helps reduce plaque, prevent tartar, and freshen bad breath. IngredientsActive Ingredients per 330mg Scoop: A.N ProDen (Specially selected sea kelp) 330mg. Inactive Ingredients: None Feeding GuidelinesDirections for daily feeding. Scoop included. Small dogs and cats up to 25 lbs: 1 scoop.Medium dogs 25 to 50 lbs: 2 scoops.Large and giant dogs over 50 lbs: 3 scoops.Give once daily during feeding time. Results are normally seen within 3 to 8 weeks of continued use. Warning:Dogs having problems with the thyroid gland must be careful with their intake of iodine. Since kelp, including our unique ingredient, have a naturally high iodine content, we do not recommend that dogs with thyroid problems use this product. Store in a cool, dry place.