Controls PPID Symptoms in Horses Product Description PRASCEND is an FDA-approved oral tablet formulated for horses diagnosed with Pituitary Pars Intermedia Dysfunction, commonly known as Equine Cushing’s Disease. It contains pergolide mesylate, a dopamine receptor agonist that helps regulate hormone levels linked to PPID. Daily administration supports improvement in clinical signs such as hirsutism, abnormal fat distribution, and muscle wasting when used as directed by a veterinarian. Benefits Hormone Level Regulation Aid: Designed to help bring elevated ACTH levels closer to normal in PPID affected horses. Clinical Symptom Management: Helps address long coats, excessive sweating, muscle thinning, and unusual fat deposits. Documented Treatment Results: Proven effectiveness observed in more than three out of four horses by Day 180. Adaptable Dosage Approach: Dosage can be fine tuned based on lab results and the horse’s clinical response. Variants Available in 3 sizes: 1 Tablet, 60 tablets, and 160 tablets. Ingredients Active Ingredients Pergolide mesylate 1 mg per tablet How to Use Recommended-Dosage Chart Body Weight 2 mcg per kg 4 mcg per kg 136 to 340 kg (300 to 749 lb) 0.5 tablet 1 tablet 341 to 567 kg (750 to 1,249 lb) 1 tablet 2 tablets 568 to 795 kg (1,250 to 1,749 lb) 1.5 tablets 3 tablets 796 to 1,022 kg (1,750 to 2,249 lb) 2 tablets 4 tablets Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet. Dosage & Administration Instructions Approved Starting Dose: Is labeled for an initial dosage of 2 mcg per kg body weight once daily. Dose Adjustment Range: Dosage is approved for adjustment based on endocrine testing response, not exceeding 4 mcg per kg daily. Tablet Scoring: Tablets are scored and labeled to allow dosing to the nearest one-half tablet increment. Prescription Status: Federal law restricts this product to use by or on the order of a licensed veterinarian. Additional Information Precautions Breeding Use: The manufacturer has not evaluated or confirmed the safety of this product for use in breeding horses, pregnant mares, or lactating animals. Drug Interactions: Using this medication alongside dopamine antagonists may lessen its effectiveness because the drugs work against each other pharmacologically. Protein Binding: Pergolide binds strongly to proteins, so extra care is needed when it is given with other medications that also have high protein-binding properties. Human Exposure: To reduce the risk of accidental human exposure during handling, the tablets should not be crushed. Possible Side Effects Decreased Appetite: Inappetence was commonly reported, particularly during the first month of treatment in clinical studies. Gastrointestinal Signs: Colic and loose stool have been reported during both pre-approval and post-approval monitoring. Behavior Changes: Behavioral effects such as agitation, aggression, or increased activity have been observed in some horses. Laminitis Risk: Both new and recurring cases of laminitis were reported during clinical safety evaluations. Storage Information Storage Temperature Guideline: The product should be kept at temperatures no higher than 25°C or 77°F to maintain quality. Secure Storage: Must be stored securely to prevent accidental ingestion by dogs, cats, or other animals. Shipping & Return We offer ground, express, priority, and international delivery; see our shipping policy for details. For return instructions or product concerns, please refer to our detailed refund policy. Prescription items are NON-RETURNABLE and NON-REFUNDABLE. Frequently Asked Questions Q1: What is PRASCEND used for in horses? Ans: PRASCEND is approved by the FDA to help manage clinical signs linked to Pituitary Pars Intermedia Dysfunction in horses. When used with veterinary guidance, it helps address hormone-driven concerns such as long or abnormal hair growth, uneven fat buildup, muscle loss, and other signs commonly seen with PPID. Q2: How does PRASCEND work in horses with PPID? Ans: PRASCEND contains pergolide mesylate, a dopamine receptor agonist. In horses with PPID, it helps stimulate dopamine receptors, which have been shown to reduce elevated ACTH and other related hormone levels involved in the disease process. Q3: Is PRASCEND a prescription medication? Ans: Yes, PRASCEND is a prescription-only veterinary medication. Federal law restricts its use to horses treated by or on the order of a licensed veterinarian, ensuring appropriate diagnosis, dosing oversight, and ongoing monitoring during treatment. Q4: What are the common side effects reported with PRASCEND? Ans: The most commonly reported side effects include decreased appetite, lethargy, diarrhea, colic, behavioral changes, and laminitis. Many cases were transient and occurred early in treatment, though post-approval reports indicate effects may also occur after dose adjustments. Q5: How should PRASCEND be stored? Ans: PRASCEND tablets should be stored at temperatures of 25°C or 77°F or lower. Keep the product in a safe place to avoid accidental access by dogs, cats, or other animals.
