Pro Bono® provides the nutritional support needed to maintain healthy bone formation. The single-serving AM and PM packets make Pro Bono® convenient, while separating the calcium and strontium servings for better absorption. Clinical Applications Convenient, Multi-Faceted, Bone Building Protocol Increases Skeletal Strength Promotes Healthy Bone Density Improves Bone Remodeling Provides a Comprehensive Blend of Foundational Micronutrients Bone mineral density is a major determinant of bone mass and is the most commonly measured quality of bone. A number of factors contribute to bone mineral density, including lifestyle factors (regular physical activity, not smoking, minimizing stress levels) and maintaining hormonal balance. Consuming a healthy diet and ensuring optimal levels of bone-building vitamins and minerals are a key therapeutic consideration for preserving bone strength. BMD is determined by a lifelong process called bone remodeling. Bone remodeling occurs when bone tissue is removed from the skeleton (bone resorption) and new bone tissue is formed. Osteoclasts are cells involved with breaking down bone, while osteoblasts create a protein matrix primarily of collagen, resulting in the remineralization of bone and thereby promoting bone formation. While calcium is an effective starting point for promoting bone health, other nutrients are required for bone mineralization. Nutrients such as strontium, magnesium, vitamin D, K and C, B complex vitamins, and trace minerals significantly enhance bone remodeling and increase bone strength. Pro Bono® provides a comprehensive approach to bone health by offering a full spectrum of nutrients that are required in the bone mineralization process. Pro Bono® also contains nutrients that help maintain an optimal osteoclast to osteoblast ratio. Suggested Use: 2 packets per day, one AM packet in the morning and one PM packet in the evening or as recommended by your health care professional. Maintenance: 1 packet per day, alternating one AM packet on odd days and one PM packet on even days or as recommended by your health care professional. Strontium Strontium is a mineral that is similar to the physical and chemical properties of calcium. Research has shown strontium to provide all natural bone support through its ability to increase the formation of osteoblasts while decreasing the formation of osteoclasts. Strontium also provides an anabolic effect on bone by stimulating bone morphogenic proteins and enhancing calcium deposition and mineralization in the bone matrix. Calcium Nearly 99% of the calcium within the adult skeletal system exists as a complex paired with phosphorus, called hydroxyapatite. It is commonly advised that individuals past early adolescence consume 1,000 to 1,500 mg/ day from dietary or supplement sources to support bone formation. Pro Bono® is formulated with calcium citrate malate and calcium hydroxyapatite to improve absorption and support optimal bone health. Magnesium Magnesium plays a major role in bone formation as approximately 50% of magnesium found in the body is found in the bone. Magnesium plays numerous roles in bone health, including increasing calcium absorption, acting as a cofactor for alkaline phosphatase activation and supporting vitamin D3 conversion in the body. Magnesium deficiency is very common; many Americans fail to acquire even the estimated average requirement (EAR). Magnesium deficiency can also be exacerbated due to factors such as excess consumption of alcohol, salt, coffee, phosphoric acid in sodas, and long-term stress. Vitamin D3 (Cholecalciferol) Vitamin D is a steroid vitamin that is known for its role in supporting bone health and aiding in the absorption of calcium and phosphate from the GI tract. Vitamin K1 (Phytonedione) and Vitamin K2 (Menaquinone) Vitamin K is responsible for synthesizing osteocalcin, a protein involved in calcium transport and properly embedding calcium into bone tissue. Vitamin K has also been shown to decrease the activity of osteoclasts, which helps to maintain bone formation and strength. Vitamin K works synergistically with vitamin D3 to improve calcium absorption and helps to bind newly absorbed calcium to the bone matrix. Boron Boron supplementation reduced urinary excretion of calcium and magnesium and increased blood levels of 17 betaestradiol and testosterone in postmenopausal women in one study. Improving boron levels has been shown to support bone health.
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