✦ Verified product
Pseudo-UTP, 100mM Solution
USD 52.50
Grade
Amount/Package
Hongene Online Store
Verified independent store
→
.rte-hr { background: linear-gradient(to right, white, #162F65); border: 0; height: 1px; margin-top: 20px; } .rte-des-lists { display: flex; flex-wrap: wrap; gap: 25px; padding: 0
10px; margin-bottom: 25px; } .rte-list-card { flex: 1; background: rgba(239, 238, 236, 0.3); border-radius: 10px; padding: 20px; box-shadow: 0px 3px 10px rgba(22, 47, 101, 0.2); transition: transform 0.3s; min-width: 290px; position: relative; } .rte-list-card:hover { transform: translateY(-5px); } .rte-list-icon { width: 25px; height: 25px; margin: 0px 5px -5px 0px; fill: currentColor; } .rte-list-card h3 { font-size: 1.2em; padding-bottom: 8px; margin-bottom: 8px; color: #3361ac; } .rte-dashed-list-title { border-bottom: dashed rgba(193, 212, 231); } .rte-list-feature { border-left: solid 3px #3361ac; padding: 3px 0 3px 10px; margin: 0 5px 5px 0; } .rte-list-feature svg { width: 10px; height: 10px; margin-bottom: -5px; fill: #3361ac; } .rte-cite cite { display: block; margin-bottom: 8px; } Pseudouridine-5’-triphosphate (ΨTP) is a naturally occurring, modified uridine nucleotide supplied for enzymatic incorporation into RNA during IVT using RNA polymerases such as T7 RNA polymerase. When incorporated into RNA, pseudouridine can reduce innate immune recognition compared with unmodified uridine and improve RNA stability and translational performance. The 100 mM disodium salt solution provides ΨTP in a highly soluble, ready-to-use form suitable for both routine laboratory applications and high-consistency manufacturing environments. Applications RNA Biology & Structural Studies ΨTP is widely used to investigate the effects of RNA modifications on secondary structure, folding, and stability.[1][2] IVT & RNA Engineering Used in IVT systems to generate high-quality and modified mRNA with improved performance.[3] Features High purity, nuclease-free, and extra-low endotoxin: suitable for sensitive biochemical assays. Ready-to-use: 100 mM solution eliminates the need for weighing and dissolution. Stable disodium salt form: ensures consistent pH and long-term storage. Reference [1] 1.Davis, Darrell R. "Stabilization of RNA stacking by pseudouridine." Nucleic acids research 23, no. 24 (1995): 5020-5026. [2] 2.Kierzek, Elzbieta, Magdalena Malgowska, Jolanta Lisowiec, Douglas H. Turner, Zofia Gdaniec, and Ryszard Kierzek. "The contribution of pseudouridine to stabilities and structure of RNAs." Nucleic acids research 42, no. 5 (2014): 3492-3501. [3] 3.Karikó, Katalin, Hiromi Muramatsu, Frank A. Welsh, János Ludwig, Hiroki Kato, Shizuo Akira, and Drew Weissman. "Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability." Molecular therapy 16, no. 11 (2008): 1833-1840.
