Supplement Facts & Directions Supplement Facts Serving Size: 50 milligrams Servings Per Container: Varies Amount Per Serving % Daily Value* Vitamin B6 (from Pyridoxine HCl) 41 mg 2032% * Percent Daily Values are based on a 2,000 calorie diet.† Daily Value Not Established ‡ These supplement facts may vary from the product you receive. Please call for exact numbers. Other Ingredients: None Contains: Free of: Added Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives. Directions: As a dietary supplement, take 50 mg up to twice daily or as directed by a physician. An accurate gram weight scale is recommended. Warning: If you are pregnant, nursing, taking any medications, or have any medical conditions consult your physician before use. DO NOT take more than 125 mg per day. Keep out of reach of children. Product Details What is Pyridoxine Hydrochloride? Pyridoxine hydrochloride is the salt form of vitamin B6. Once ingested, it converts into its active form pyridoxal 5'-phosphate (PLP). It is one of the eight water-soluble B vitamins, and it is an essential coenzyme for more than 140 enzyme reactions. Some of its crucial metabolic functions include metabolizing lipids and fatty acids, synthesizing amino acids and neurotransmitters, and generating glucose as fuel for the brain. What Does Vitamin B6 Do? Vitamin B6 plays an important role in metabolizing protein, fat, and carbohydrates. It’s a cofactor for synthesizing numerous neurotransmitters. It also supports red blood cell production. It helps synthesize hemoglobin and improves its ability to bind to and release oxygen. Vitamin B6 is so critical to producing red blood cells that a deficiency can cause microcytic anemia. It also supports healthy immune function, response, and tolerance. Vitamin B6 Deficiency Symptoms Certain populations are at greater risk of developing a vitamin B6 deficiency. These include individuals with kidney, liver, or digestive disorders. Certain autoimmune conditions, pregnancy, smoking, obesity, and alcohol abuse may cause a vitamin B6 deficiency. A vitamin B6 deficiency can trigger a multitude of symptoms. These include: Fatigue Pain, pins and needles sensations, or tingling in the hands and feet (peripheral neuropathy) Oily and flaky rashes on the face, neck, and chest (seborrheic dermatitis) Painful cracks at the corners of the mouth (cheilosis) A smooth, sore, red, and inflamed tongue (glossitis) Frequent illnesses and infections due to a weakened immune system Elevated blood levels of homocysteine Anemia Potential Vitamin B6 Benefits Vitamin B6 for Energy Like the other b vitamins, pyridoxine hydrochloride can increase energy. It helps break down glucose for energy, and it can also synthesize glucose from non-carbohydrate sources if glucose becomes unavailable. Glucose is the sole source of energy for the brain, with the exception of ketones during periods of fasting. Vitamin B6 for Mood Vitamin B6 may improve mood in several ways. Individuals with low B6 are more susceptible to mood imbalances. High homocysteine levels can also have a negative effect on mood. Vitamin B6 supplements can address both these issues by replenishing B6 and lowering homocysteine levels. Vitamin B6 is a critical component for creating mood-regulating neurotransmitters as well, including dopamine, epinephrine, gamma-aminobutyric acid (GABA), norepinephrine, and serotonin. Vitamin B6 for Morning Sickness Vitamin B6 has a well-documented history of relieving morning sickness, and it may help with non-pregnancy-related nausea too. Nausea is a common symptom of early pregnancy, but it can culminate in severe dehydration if vomiting is excessive. Researchers don’t fully understand how B6 improves nausea, but one hypothesis is that vitamin B6 plays several critical roles during pregnancy. One study found that women who took vitamin B6 for morning sickness found relief within five days. Another study noted that vitamin B6 combined with ginger reduced nausea and vomiting by 31% after four days of use. Vitamin B6 similarly improved morning sickness symptoms when paired with an antihistamine. Because vitamin B6 is so well-researched, it’s recognized as safe in normal doses during pregnancy. Vitamin B6 and Heart Health Vitamin B6 may improve heart health by lowering homocysteine levels. Elevated homocysteine increases the risk of heart disease, blood clots, and stroke. Insufficient B6 also almost doubles the risk of heart disease, and it may contribute to high cholesterol and artery blockages. Vitamin B6 Benefits for PMS Vitamin B6 supplements may benefit menstruating women by relieving their PMS symptoms. It may help alleviate irritability, low mood, mood swings, fatigue, and nervousness. It may alleviate emotional symptoms of PMS as well due to its interactions with mood regulating neurotransmitters. Potential Vitamin B6 Side Effects Vitamin B6 is water-soluble, and the body usually excretes any excess. Trials note that vitamin B6 doesn’t cause adverse reactions when taken at typical doses. However, high amounts of vitamin B6 in excess of 1g per day (more than 10 times the recommended daily allowance) over a long period of time can damage nerves. References https://pubchem.ncbi.nlm.nih.gov/compound/Pyridoxine-hydrochloride http://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/ http://lpi.oregonstate.edu/mic/vitamins/vitamin-B6 https://www.ncbi.nlm.nih.gov/pubmed/3300730?dopt=Abstract https://www.ncbi.nlm.nih.gov/pubmed/3300730?dopt=Abstract https://pubchem.ncbi.nlm.nih.gov/compound/Vitamin%20B6 https://lpi.oregonstate.edu/mic/vitamins/vitamin-B6 https://chem.libretexts.org/Bookshelves/Biological_Chemistry/Supplemental_Modules_(Biological_Chemistry)/Metabolism/Anabolism/Gluconeogenesis https://www.sciencedirect.com/science/article/pii/B978012095461200014X https://pubmed.ncbi.nlm.nih.gov/30037155 https://books.google.com/books?id=1CMHiWum0Y4C https://www.ncbi.nlm.nih.gov/pubmed/24574047 https://www.ncbi.nlm.nih.gov/pubmed/20373888 https://www.ncbi.nlm.nih.gov/pubmed/7573262 https://www.ncbi.nlm.nih.gov/pubmed/17621727 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019938 https://www.drugs.com/monograph/pyridoxine-hydrochloride.html https://www.hsph.harvard.edu/nutritionsource/vitamin-b6/ https://www.ncbi.nlm.nih.gov/pubmed/17045461 https://www.ncbi.nlm.nih.gov/pubmed/16768830 https://www.ncbi.nlm.nih.gov/pubmed/2558186 https://www.ncbi.nlm.nih.gov/pubmed/10746516 Tested by Accredited 3rd Party Labs PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here. *NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
