Description Rapamycin was used as a kind of original antifungal antibiotic, which is produced by Streptomyces hygroscopicus. Now it has been used in the prevention of transplant rejection because of its immunosuppressive effect. It also exhibits activity against several transplantable tumors and slightly activity to inactive against leukemias. The immunosuppressive effect of Rapamycin is exerted by inhibiting the activation and proliferation of T cells. Rapamycin binds to FK-binding protein 12 (FKBP12) and forms the rapamycin-FKBP12 complex, which regulates an enzyme that plays an important role in the progression of the cell cycle. Specifications Item Value Chemical Name Rapamycin CAS No. 53123-88-9 Molecular Formula C51H79NO13 Molecular Weight 914.17 Purity ≥99% IC50 and Target 0.1 nM in HEK 293 Cells Solubility DMSO: 50 mg/mlDMSO: 125 mg/ml (136.74 mM, with Ultrasonic)Ethanol: 50 mg/ml Features High Purity (≥99%) Ensures reliable and reproducible results in sensitive biochemical and cellular assays. Potent mTOR Pathway Inhibitor Forms a complex with FKBP12 to regulate key enzymes involved in cell cycle progression. Well-Characterized Biological Activity Demonstrates strong inhibitory activity in cellular models, including HEK 293 cells. Excellent Solubility Readily soluble in DMSO and ethanol for convenient preparation of stock solutions. Research-Grade Quality Suitable for advanced studies in immunology, oncology, and signal transduction. Applications mTOR signaling pathway research Immunology and T-cell activation studies Cancer and tumor biology research Cell cycle and proliferation analysis Mechanistic studies in molecular and cellular biology Documents MSDS COA Data Sheet
