Recombinant Human FGF-2/ Basic FGF Protein Catalog number: B2018644 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 1 ug Molecular Weight or Concentration: ~16 kDa Supplied as: Powder Applications: a molecular tool for various biochemical applications Storage: -20°C Keywords: FGF-β, basic fibroblast growth factor, bFGF Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References Benington LR, Rajan G, Locher C, Lim LY. Stabilisation of Recombinant Human Basic Fibroblast Growth Factor (FGF-2) against Stressors Encountered in Medicinal Product Processing and Evaluation Pharmaceutics. 2021 Oct 21;13(11):1762. Morscheid YP, Venkatesan JK, Schmitt G, Orth P, Zurakowski D, Speicher-Mentges S, Menger MD, Laschke MW, Cucchiarini M, Madry H. rAAV-Mediated Human FGF-2 Gene Therapy Enhances Osteochondral Repair in a Clinically Relevant Large Animal Model Over Time In Vivo Am J Sports Med. 2021 Mar;49(4):958-969. Lee TH, Kim WT, Ryu CJ, Jang YJ. Optimization of treatment with recombinant FGF-2 for proliferation and differentiation of human dental stem cells, mesenchymal stem cells, and osteoblasts Biochem Cell Biol. 2015 Aug;93(4):298-305. Amini M, Venkatesan JK, Nguyen TN, Liu W, Leroux A, Madry H, Migonney V, Cucchiarini M. rAAV TGF-β and FGF-2 Overexpression via pNaSS-Grafted PCL Films Stimulates the Reparative Activities of Human ACL Fibroblasts Int J Mol Sci. 2023 Jul 6;24(13):11140. Madry H, Kohn D, Cucchiarini M. Direct FGF-2 gene transfer via recombinant adeno-associated virus vectors stimulates cell proliferation, collagen production, and the repair of experimental lesions in the human ACL Am J Sports Med. 2013 Jan;41(1):194-202. Zhang M, Matinlinna JP, Tsoi JKH, Liu W, Cui X, Lu WW, Pan H. Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview J Orthop Translat. 2019 Oct 8;22:26-33. Frisch J, Venkatesan JK, Rey-Rico A, Zawada AM, Schmitt G, Madry H, Cucchiarini M. Effects of rAAV-mediated FGF-2 gene transfer and overexpression upon the chondrogenic differentiation processes in human bone marrow aspirates J Exp Orthop. 2016 Dec;3(1):16. Valtink M, Knels L, Stanke N, Engelmann K, Funk RH, Lindemann D. Overexpression of human HMW FGF-2 but not LMW FGF-2 reduces the cytotoxic effect of lentiviral gene transfer in human corneal endothelial cells Invest Ophthalmol Vis Sci. 2012 May 31;53(6):3207-14. Stehle M, Amini M, Venkatesan JK, Liu W, Wang D, Nguyen TN, Leroux A, Madry H, Migonney V, Cucchiarini M. Commitment of human mesenchymal stromal cells towards ACL fibroblast differentiation upon rAAV-mediated FGF-2 and TGF-β overexpression using pNaSS-grafted PCL films Biotechnol Bioeng. 2024 Jun 14.
