.biofargo-table-wrapper {overflow-x: auto;margin: 20px 0;-webkit-overflow-scrolling: touch;}.biofargo-spec-table {width: 100%;border-collapse: collapse;border: 1px solid #dee2e6;min-width: 600px;background: #fff;}.biofargo-spec-table th,.biofargo-spec-table td {border: 1px solid #dee2e6;padding: 12px;vertical-align: middle;white-space: normal;word-break: break-word;}@media (max-width: 600px) {.biofargo-table-wrapper {border: 1px solid #eee;border-radius: 8px;padding: 6px;background: #fff;}.biofargo-spec-table {min-width: 720px;}} Description IL-1α (Interleukin-1α), a key member of the interleukin-1 (IL-1) family, shares a similar β-trefoil topology with other IL-1 family members such as IL-1β, despite low sequence homology. Like IL-1β, it exerts its biological functions by binding to the interleukin-1 receptor (IL-1R). IL-1α is a pleiotropic cytokine that plays a central role in inflammation, immune responses, and cell proliferation.In in vitro cell culture, IL-1α stimulates monocytes/macrophages and dendritic cells to secrete other cytokines, thereby mimicking an inflammatory environment. It also promotes the proliferation of fibroblasts and endothelial cells, making it a useful tool in wound healing and angiogenesis research. Specifications Product Details Cat. No. Y01921H Purity ≥95%, by SDS-PAGE (under reducing (R)& Non-reducing conditions, visualized by Coomassie staining). Endotoxin ≤100 EU/mg by the LAL method. Bioactivity Measured by its ability to induce NF-kB reporter activity by the reporter gene assay. The ED50 for this effect is ≤0.05ng/mL. Accession P01583 Species Human Expression System E. coli Mol. Weight 18.0kDa Expression Region Ser113-Ala271 Tag Info Tag free Formulation Lyophilized Buffer PB, 5% Trehalose and 0.01% Tween 80, pH7.4. Size 50μg/1mg Lead Time Products are in stock, but custom products may require further consultation. Reconstitution It is recommended to redissolve in sterile deionized water. Shipping The product is shipped with blue ice. Features ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results. ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells. ✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches. ✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements. Applications Hematology Involved in inflammation-driven hematopoietic stress, affecting myeloid cell activation. Immunology Classical pro-inflammatory cytokine that activates innate immunity and amplifies inflammatory cascades. Cell Biology Regulates inflammatory responses, stress signaling, and intercellular communication. Data Figures Figure 1: Human IL-1A (Cat. No. Y01921H) induces NF-kB reporter activity by the reporter gene assay. The ED50 for this effect is ≤0.05 ng/mL. The activity of Human IL-1A (Cat. No. Y01921H) was higher than the other competing product. Instructions for Use Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use. Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results. Do not mix with other similar products to avoid cross-reactivity and potential interference. Cautions • Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications. • Preservation: Handle according to instructions to preserve its activity and stability. • Support: Contact our technical support team if you encounter any issues or questions. Documents 📄 Download COA
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